中国全科医学2017，Vol.20Issue(8)：928-933,6.DOI:10.3969/j.issn.1007-9572.2017.01.y09
血清瘦素/脂联素比值与2型糖尿病患者轻度认知功能障碍相关性研究
Association between Leptin/Adiponectin Ratio and Type 2 Diabetes Mellitus with Mild Cognitive Impairment
摘要
Abstract
Objective To explore the association between leptin/adiponectin (L/A) ratio and type 2 diabetes mellitus (T2DM) with mild cognitive impairment (MCI).Methods We enrolled 30 T2DM patients in Endocrinology Department of the First Affiliated Hospital of Anhui Medical University from March to July in 2016 as T2DM group,30 T2DM patients with macroangiopathy as T2DM + Ⅴ group and 30 T2DM patients with obesity as T2DM + OB group,another 30 healthy individuals who received physical examination as control group.We compared the obtained clinical data [gender,age,years of education,height,weight,BMI,waistline,hip circumference,waist-to-hip ratio (WHR),svstolic blood pressure (SBP) and diastolic blood pressure (DBP)] and results of laboratory testing [fasting blood glucose (FBG),total cholesterol (TC),triacylglycerol (TG),high-density lipoprotein cholesterol (HDL-C),low-density lipoprotein cholesterol (LDL-C),very low-density lipoprotein cholesterol (VLDL-C),HbA1,serum creatinine (Scr),urea nitrogen (BUN),LEP,APN and L/A ratio] among the four groups.We evaluated cognitive function of the four groups with the Montreal Cognitive Assessment (MoCA) (MoCA score ＜ 26 points was defined as MCI).Pearson correlation analysis and multivariable linear regression analysis were used to study the factors related to MoCA score.Results The differences in weight,BMI,waistline,hip circumfference,WHR,SBP,DBP,FBG,TG,HDL-C,VLDL-C,HbA1c,BUN,LEP,APN,L/A ratio among the four groups were statistically significant (P ＜ 0.05).The differences in MoCA score and positive rate of MCI among the four groups were statistically significant (P ＜0.05);MoCA score in T2DM group,T2DM + Ⅴ group,T2DM + OB group was lower than that in control group (P ＜ 0.05);positive rate of MCI in T2DM + Ⅴ group,T2DM + OB group was higher than that in control group (P ＜ 0.007).Pearson correlation analvsis showed that MoCA score was positively correlated with years of education (r =0.532,P ＜0.001) and APN (r =0.652,P ＜0.001) while negatively correlated with BMI (r =-0.192,P =0.035),waistline (r =-0.182,P =0.046),hip circumference (r =-0.184,P =0.045),FBG (r =-0.297,P =0.001),HbA1c (r=-0.297,P=0.001),LEP (r=-0.722,P＜0.001) and L/A ratio (r=-0.793,P＜0.001).The results of multivariable linear regression analysis demonstrated that MoCA score was positively correlated with years of education [β3=0.197,95c％ CI (0.109,0.284),P ＜0.001],while negatively correlated with L/A ratio [β3 =-2.532,95％ CI (-2.966,-2.099),P ＜ 0.001].Conclusion Macroangiopathy and obesity may be the risk factors aggravating the severity of MCI.L/A ratio may become a new pre-clinical sign of T2DM patients with MCI,which is of important reference significance in the early detection and prevention of MCI.关键词
糖尿病,2型/瘦素/脂联素/轻度认知障碍Key words
Diabetes mellitus/type 2/Leptin/Adiponectin/Mild cognitive impairment分类
医药卫生引用本文复制引用
李远,章秋,刘安诺,代芳,尹倩倩..血清瘦素/脂联素比值与2型糖尿病患者轻度认知功能障碍相关性研究[J].中国全科医学,2017,20(8):928-933,6.基金项目
安徽省教育厅自然科学基金资助项目(KJ2016A330) （KJ2016A330）
