中国全科医学2017，Vol.20Issue(8)：939-942,947,5.DOI:10.3969/j.issn.1007-9572.2017.08.010
慢性乙型肝炎病毒感染者血清流行病学研究
Seroepidemiologic Study of Chronic HBV-infected Patients
摘要
Abstract
Background With the development and research of clinical cure of chronic hepatitis B (CHB),testing of serum immune markers of HBV and HBV DNA load can provide reference for the clinical treatment study of CHB.Objective To analyze the serological pattern in chronic HBV-infected patients and its correlation with HBV DNA load.Methods The subjects enrolled in this study were the chronic HBV-infected outpatients and inpatients (n =2 425) who received treatment in Department of Infectious Diseases,First Affiliated Hospital of Kunming Medical University from March to December 2015.Serum immune markers and HBV DNA load were measured in the subjects by ARCHITECT i2000SR Immunoassay Analyzer with matched chemiluminescence reagent,and PGQ-PCR Amplification with HBV nucleic acid quantitative detection kit,respectively.HBsAg,HBsAb,HBeAg,HBeAb and HBcAb was labeled as 1,2,3,4,and 5,respectively.And their serological patterns were analyzed.Results Of the 7 serological patterns found in the 2 425 patients with chronic HBV infection,there were 5 patterns which occupied a proportion more than 1.00％,respectively;the patterns of " 1,3,5 1,4,5 1,3,4,5 1,5" and" 1,2,3,5" accounting for 55.05％,37.69％,3.26％,1.86％ and1.53％,respectively.Therare for other patterns of " 1,2,4,5" and " 2,4,5" was 0.53％ and 0.08％,respectively.The age and HBV DNA load were significant differences among the 5 main patterns (P ＜ 0.05),but the gender was no significant differences among them (P ＞0.05).Notable difference in age distribution was observed among the 5 main patterns (x2 =266.625,P ＜ 0.001).Patterns of " 1,3,5"" 1,3,4,5 1,5" and " 1,2,3,5" mainly occurred in age groups of 21-30 and 31-40,while the pattern of " 1,3,5" chiefly in age groups of 31-40 and 41-50.In chronic HBV-infected patients with pattern of " 1,3,5",the HBV DNA load was positively correlated with HBsAg and HBeAg (P ＜ 0.05),while negatively correlated with HBcAb (P ＜ 0.05);HBsAg was positively related to HBeAg (P ＜ 0.05).Among chronic HBV-infected patients with pattern of " 1,4,5 1,3,4,5",the HBV DNA load was positively associated with HBeAg and HBcAb (P ＜ 0.05).HBV DNA load was positively associated with HBsAg,HBeAg and HBcAb,HBsAg was positively associated with HBeAg in chronic HBV-infected patients with pattern of " 1,2,3,5" (P ＜ 0.05).Conclusion There were 7 kinds of patterns in chronic HBV-infected patients with positive HBV DNA,predominated by the patterns of " 1,3,5" and " 1,4,5" Significant differences by age and HBV DNA load existed among the 5 main patterns.关键词
乙型肝炎病毒/病毒载量/血清流行病学研究Key words
Hepatitis B virus/Viral load/Seroepidemiologic studies分类
医药卫生引用本文复制引用
陈红英,丁洁,游晶..慢性乙型肝炎病毒感染者血清流行病学研究[J].中国全科医学,2017,20(8):939-942,947,5.基金项目
云南省科技计划资助项目(2011WS0053,2011FZ121,2012WS0028) （2011WS0053,2011FZ121,2012WS0028）
