中国比较医学杂志2017，Vol.27Issue(4)：9-13,5.DOI:10.3969.j.issn.1671-7856.2017.04.002
蕨麻猪与巴马小型猪脏器指数及低氧相关基因的比较
Comparison of organ coefficients and expression of hypoxia-related genes in the Bama and Juema minipigs
摘要
Abstract
Objective To compare the organ coefficients and expressions of hypoxia-related genes in Bama and Juema pigs.Method Real-time quantitative PCR was used to detect the changes of hypoxia gene expressions in the heart,liver,spleen,lung,and kidney of Juema and Bama miniature pigs.Results The organ coefficients of kidney and spleen of Juema pigs were significantly lower than Bama miniature pigs (P<0.05 for both).The heart and lung coefficients of Juema pigs were significantly higher than that of Bama miniature pigs (P<0.05 for both).The VEGF and HIF-1α expressions in the lung and kidney in Juema pigs were significantly higher than Bama pigs (P<0.05 or P<0.01).Only the EPO expression in in the lung of Juema pigs was significantly higher than that of the Bama miniature pigs (P<0.05).Conclusions These results indicate that the variation in organ coefficients may be resulted from evolutionary factors such as adaptiveness to environmental physical and energy conditions,pathogens,and energy metabolism demands,etc.in combination.Juema miniature pigs showing a significantly higher expression of hypoxia-related genes than that in Bama minipigs indicate that it has a strong plateau adaptability by higher gene expressions.关键词
蕨麻猪/巴马小型猪/脏器指数/低氧相关基因/比较Key words
Juema minipig/Bama minipig/Organ coefficient/Hypoxia-related gene/High plateau分类
医药卫生引用本文复制引用
牛廷献,王红义,郭晓宇,陆璐,申健,肖攀,冯小明..蕨麻猪与巴马小型猪脏器指数及低氧相关基因的比较[J].中国比较医学杂志,2017,27(4):9-13,5.基金项目
甘肃省自然科学基金项目(1308RJZA178). （1308RJZA178）
