中国比较医学杂志2017，Vol.27Issue(4)：89-93,5.DOI:10.3969.j.issn.1671-7856.2017.04.015
母婴分离应激对rd新生小鼠行为的影响
Effect of maternal separation stress on behavior of neonatal rd mice
摘要
Abstract
Objective To evaluate the effect of maternal separation stress on the behavior of neonatal rd mice.Methods Neonatal rd mice were divided into maternal separation (MS) group (n=9) and control group (n=9).MS-stress was induced in the MS group by 4-hour-separation per day for 28 days.Open field test,elevated plus maze test,forced swim test and tail suspension test were used to evaluate the anxiety-like and depression-like behavior of the neonatal rd mice.Results The stay time and distance travelled of MS group in the central zone were 0.88％ and 28.17±5.65 cm,respectively,significantly shorter than that of the control group (2.61％,109.9±9.79 cm.P =0.04,P =0.001).Compared with the control group,the stay time in open arms of the MS group was significantly decreased (P<0.01),while the immobility time in forced swim test and tail suspension test of the MS group were 126.5±10.22 s and 21.56±6.83 s,significantly longer than that of the control group (77.75±16.83 s,P =0.02,7.37±3.22 s,P =0.03).Conclutions The 28-day maternal separation stress can significantly increase the anxiety-like and depression-like behavior in neonatal rd mice.关键词
rd小鼠/母婴分离/开放场实验/十字高架实验/强迫游泳实验/悬尾实验Key words
rd mice/neonatal/Maternal separation/Stress/Open field test/Elevated plus maze test/Force swim test/Tail suspension test/Anxiety-like behavior/Depression-like behavior分类
医药卫生引用本文复制引用
张传领,邸桐,王文婧,牛丽丽,肖瑞..母婴分离应激对rd新生小鼠行为的影响[J].中国比较医学杂志,2017,27(4):89-93,5.基金项目
国家自然科学基金(编号31260260),内蒙古医科大学博士启动基金(编号:nybq2010zcl). （编号31260260）
