中国现代医学杂志2017，Vol.27Issue(7)：1-4,4.DOI:10.3969/j.issn.1005-8982.2017.07.001
内脂素对2型糖尿病kkay小鼠骨骼肌组织PI3K和GLUT-4的影响
Influence of visfatin on PI3K and GLUT-4 in skeletal muscle of diabetic kkay mice
摘要
Abstract
Objective To observe the influence of visfatin on glucose transporter 4 (GLUT-4) and phosphatidylinositol 3-kinase isoform (PI3K) in skeletal muscle of kkay mice. Methods C57BL/6J mice were randomly divided into normal diet group (group CON) and high-fat diet group (group HFD); kkay mice were divided into diabetic group (group DM) and visfatin treatment group (group V). PI3K and GLUT-4 mRNA and protein expressions in the skeletal muscle were measured by qRT-PCR and Western blot. Results In the group V, blood glucose significantly decreased after intraperitoneal injection of visfatin (p =0.013). PI3K and GLUT-4 mRNA and protein expressions of skeletal muscle were significantly lower in the group DM than in the groups CON and HFD ( p< 0.05). PI3K and GLUT-4 mRNA and protein expressions of skeletal muscle were significantly higher in the group V than in the group DM ( p<0.05). Conclusions Visfatin increases the expressions of PI3K and GLUT-4 in skeletal muscle.关键词
内脂素/kkay小鼠/骨骼肌/PI3K/GLUT-4Key words
visfatin/kkay mice/skeletal muscle/PI3K/GLUT-4分类
医药卫生引用本文复制引用
王倩,阳琰,陈其荣,张晗,高琳,廖鑫,王茜..内脂素对2型糖尿病kkay小鼠骨骼肌组织PI3K和GLUT-4的影响[J].中国现代医学杂志,2017,27(7):1-4,4.基金项目
国家自然科学基金(No:81660142) （No:81660142）
