中国现代医学杂志2017，Vol.27Issue(7)：5-8,4.DOI:10.3969/j.issn.1005-8982.2017.07.002
薯蓣丸对乳腺癌化疗小鼠免疫功能的影响
Effect of Dioscorea pills on immunity of mice receiving chemotherapy for breast cancer
摘要
Abstract
Objective To observe the effect of Dioscorea pills on the immunity of mice with breast cancer after chemotherapy and its mechanism of action. Methods BALB/c mice were randomly divided into blank group, model group, chemotherapy group and chemotherapy plus TCM group with 8 mice in each group. Except the blank group, 24 mice in other groups were subcutaneously injected with 4T1 breast cancer cell suspension at the left abdomen to build a tumor-bearing mouse model. After tumor formation, the chemotherapy group and the chemotherapy plus TCM group were intraperitoneally injected with Docetaxel. Two days later, the chemotherapy plus TCM group was given Dioscorea pills by gavage, while the other three groups were given equal quantity of normal saline. All mice were sacrificed 21 days after treatment. The serum levels of IL-2, IL-10, IFN-γ and TNF-α were measured. Results Compared with the model group, the levels of IL-2 and IFN-γ of the chemotherapy group and the chemotherapy plus TCM group were significantly decreased, while the levels of TNF-αand IL-10 were significantly increased ( p< 0.05). Compared with the chemotherapy group, the levels of IL-2 and INF-γ of the chemotherapy plus TCM group were greatly increased, while the level of IL-10 was significantly decreased ( p< 0.05); the level of TNF-αwas slightly increased without significant difference (p>0.05). Conclusions Dioscorea pills can improve the immunity of mice with breast cancer after chemotherapy.关键词
薯蓣丸/乳腺癌小鼠/IL-2/IL-10/IFN-γ/TNF-αKey words
Dioscorea pill/mouse with breast cancer/IL-2/IL-10/IFN-γ/TNF-α分类
医药卫生引用本文复制引用
贺昀,谢甦,李丽红,赵大尉,张雲杰,关惠婷..薯蓣丸对乳腺癌化疗小鼠免疫功能的影响[J].中国现代医学杂志,2017,27(7):5-8,4.基金项目
贵州省中医药管理局中医药、民族医药科学技术研究课题基金(No:QZYY-2015-155) （No:QZYY-2015-155）
贵州省科技厅联合基金(黔科合LH字[2014]7110) （黔科合LH字[2014]7110）
