中国现代医学杂志2017，Vol.27Issue(7)：64-66,3.DOI:10.3969/j.issn.1005-8982.2017.07.015
联合检测血清胃蛋白酶原和MG7抗原在胃癌诊断中的意义
Significance of combined detection of serum MG7-Ag and pepsinogen in diagnosis of gastric cancer
王康康 1罗金键 1汪秀梅 1陈晓燕1
作者信息
- 1. 郑州大学附属郑州中心医院 消化内科,河南 郑州 450007
- 折叠
摘要
Abstract
Objective To explore the clinical value of determination of serum pepsinogen (PGⅠ), PGⅠ/PGⅡ(PGR) and MG7-Ag for diagnosis of gastric cancer. Methods A total of 120 patients were divided into 3 groups based on endoscopic and histopathological findings: 30 patients in atrophic gastritis group, 40 in gastric cancer group, and 50 in control group (with normal gastric mucosa or non-atrophic gastritis). MG7-Ag was detected by enzyme linked immunosorbent assay (ELISA), and serum PGⅠ and PGⅡ levels were measured by latex enhanced immune turbidimetry. Results PGⅠand PGR levels of the gastric cancer group were significantly lower than those in the atrophic gastritis group and the control group ( p<0. 05). MG7-Ag level of the gastric cancer group was remarkably higher than that in the atrophic gastritis group and the control group ( p< 0. 05). The positive expression rate of combined detection of serum MG7-Ag and PG level was 89.87% in the gastric cancer group and 57.77% in the atrophic gastritis group, which was significantly higher than the positive rate of the detection of PGⅠ+PGR or MG7-Ag in the corresponding group ( p< 0.05). Conclusions Combined detection of serum MG7-Ag and PG has an important value in the diagnosis of gastric cancer.关键词
胃蛋白酶原/MG7抗原/胃癌Key words
PG/MG7-Ag/gastric cancer分类
医药卫生引用本文复制引用
王康康,罗金键,汪秀梅,陈晓燕..联合检测血清胃蛋白酶原和MG7抗原在胃癌诊断中的意义[J].中国现代医学杂志,2017,27(7):64-66,3.
