摘要
Abstract
Objective To investigate the value of serum procalcitonin (PCT) in the diagnosis of postoperative infectious complications in colorectal cancer patients. Methods A total of 115 patients with colorectal cancer who had postoperative infectious complications from June 2012 to March 2015 were enrolled as infection group. In accordance with 1 : 1 matching principle, 115 cases without postoperative infectious complications during the same time were selected as control group. Serum PCT level, hypersensitive C-reactive protein (hs-CRP), WBC and neutrophil ratio were compared between the two groups on the postoperative days (POD) 1, 3 and 7. The area under the receiver operating characteristic curve (AUC) was used to evaluate the value of these indicators in diagnosis of postoperative infectious complications. Results Serum PCT level in the infection group was significantly higher than that in the non-infection group on the POD 1, 3 and 7 ( p< 0.05). Compared with the non-infection group, the proportion of patients with serum PCT level >2.0 ng/ml significantly increased, and the proportion of patients with serum PCT level <0.5 ng/ml significantly decreased in the infection group ( p< 0.05). The AUC of serum PCT level on the POD 1, 3 and 7 were 0.862, 0.887 and 0.841 respectively, which were higher than the AUC of hs-CRP, WBC and neutrophil ratio on the same day. The best positive threshold of serum PCT level on the POD 1, 3 and 7 was 1.21 ng/ml, 1.94 ng/ml and 0.63 ng/ml respectively. Conclusions For patients with colorectal cancer, serum PCT level is a quick and reliable indicator for early diagnosis of postoperative infectious complications. It is easy to detect and has high sensitivity and specificity, and is recommended as one of postoperative routine detection indexes.关键词
降钙素原/感染/结直肠癌/术后并发症Key words
procalcitonin/infection/colorectal cancer/postoperative complication分类
医药卫生
