中国循证儿科杂志2016，Vol.11Issue(3)：182-186,5.DOI:10.3969/j.issn.1673-5501.2016.03.005
抗N-甲基-D-天冬氨酸受体脑炎102例临床特征及随访
Clinical characteristics and follow-up of anti-N-methyl-D-aspartate receptor encephalitis in 102 children
张炜华 1李久伟 1王红梅 1杨欣英 1张珅 1孙欣 1邓劼 1代丽芳 1任海涛 2崔丽英 2王晓慧 1方方 1吕俊兰 1丁昌红 1陈春红 1王旭 1韩彤立 1伍妘1
作者信息
- 1. 首都医科大学附属北京儿童医院 北京,100045
- 2. 中国医学科学院中国协和医科大学 北京,100730
- 折叠
摘要
Abstract
Objective To describe the clinical manifestations and prognosis of children with anti-N-methyl-D-aspartate receptor encephalitis.Methods Clinical manifestations,lab examination,management and prognosis of children with anti-N-methyl-D-aspartate receptor encephalitis hospitalized in Neurology Department of Beijing Children's Hospital from January 2012 to December 2014 were retrospectively analyzed and the effect at the last follow-up was assessed by Modified Rankin Scale (MRS).Results A total of 102 cases diagnosed as anti-N-methyl-D-aspartate receptor encephalitis with the average onset age of (7.5 ± 4.0) years ranged from 6 months to 15.8 years were enrolled into the analysis including 38 males and 64 females.The average onset age of females was elder than that of males (P =0.009).Psychiatric disturbances was found in 40 cases and neurology disorder was found in 62 cases as the initial symptoms.The symptoms in acute stage included mental and behavior disorder (99/ 102,97.1％),dyskinesia (98/102,96.1％),speech disorder (91/102,89.2％),sleep disorder (79/102,77.5％) and central hypoventilation (7/102,6.9％),and there was no significant difference among different age groups.All cases received the first line therapy,18 (17.3％) cases received the second line therapy,14 cases(15.9％) had sequelae (MRS ≥3),3 cases died and 4 cases relapsed.Conclusion Anti-N-methyl-D-aspartate receptor encephalitis happened in different age groups,clinical manifestations were similar to adult,most of cases had favourable prognosis,but young children and those secondary to virus encephalitis had poor prognosis.关键词
儿童/抗N-甲基-D-天冬氨酸受体脑炎/临床特征/随访Key words
Pediatric/Anti-N-methyl-D-aspartate receptor encephalitis/Clinical characteristics/Follow-up引用本文复制引用
张炜华,李久伟,王红梅,杨欣英,张珅,孙欣,邓劼,代丽芳,任海涛,崔丽英,王晓慧,方方,吕俊兰,丁昌红,陈春红,王旭,韩彤立,伍妘..抗N-甲基-D-天冬氨酸受体脑炎102例临床特征及随访[J].中国循证儿科杂志,2016,11(3):182-186,5.
