中国循证儿科杂志2016，Vol.11Issue(3)：195-199,5.DOI:10.3969/j.issn.1673-5501.2016.03.007
实验室指标与川崎病并发冠状动脉损伤关联性的系统评价和Meta分析
Six biomarkers associated with coronary artery lesions secondary to Kawasaki disease: a systematic review and meta-analysis
摘要
Abstract
Objective To explore the relationship between 6 common biomarkers and kawasaki disease (KD) with coronary artery lesions(CAL) in the acute phase.Methods Case-control studies from the database of Web of Science,PubMed,The Cochrane Library,EBSCO,China National Knowledge Infrastructure,Wanfang Chinese Periodical Database and VIP Information were recruited to summarize the association between 6 biomarkers (WBC,Hb,PLT,CRP,ESR,ALB) with CAL from January 1 2000 to April 30 2016,and the biomarkers were adjusted by multivariate regression analysis.According to the inclusion and exclusion criteria the studies were selected through EndNote X7 software.The quality of the studies was evaluated by NewcastleOttawa Scale(NOS).Stata 12.0 software was applied for the meta-analysis,OR and 95％ CI were extracted from each study.The effect model was selected according to the heterogeneity results.Results Twelve clinical studies with a total of 4 900 patients,1 256patients with CAL were identified.6 factors were included.Six studies were 7 points and 4 studies were 6 points.There was no statistical significance between WBC,Hb,CRP,ESR with CAL,the results of OR and 95％ CI were as follows:0.32 (0.02-4.91),0.94 (0.88-1.01),1.11(0.97-1.26)and 1.09(0.98-1.20).PLT and ALB were related to the CAL,the results were as follows:1.020(1.001-1.039) and 0.87 (0.80-0.95).PLT and ALB were used as random model.Conclusion The major risk factors for KD with CAL in the acute stage were increased PLT and decreased ALB.关键词
川崎病/冠状动脉损伤/血小板/白蛋白/系统评价/Meta分析Key words
Kawasaki disease/Coronary artery lesions/Platelet/Albumin/Systematic review/Meta-analysis引用本文复制引用
周雪晴,罗亚玲,周天津,黄仕鑫..实验室指标与川崎病并发冠状动脉损伤关联性的系统评价和Meta分析[J].中国循证儿科杂志,2016,11(3):195-199,5.基金项目
2015年国家社会科学基金项目:15BGL191 （）
