中国循证儿科杂志2016，Vol.11Issue(3)：200-203,4.DOI:10.3969/j.issn.1673-5501.2016.03.008
济南市单中心迁延性咳嗽患儿中百日咳的横断面调查
The cross-sectional study on the prevalence of pertussis in children with protracted cough in a single center in Jinan
韩玉玲 1杨春 2丁明杰 1程璐 1孙静 1林美函 3马香1
作者信息
- 1. 山东大学齐鲁儿童医院呼吸科 济南,250022
- 2. 山东大学齐鲁儿童医院医学检验中心 济南,250022
- 3. 山东省泰山医学院 泰安,271016
- 折叠
摘要
Abstract
Objective To investigate the epidemiology of pertussis in the children with protracted cough in Jinan.Methods Outpatients and inpatients with protracted cough visiting the Department of Respiratory of Jinan Children's Hospital from January 1 to December 31 2015 were recruited to receive pertussis serum antibody and PCR detection.Information about the age of pertussis diagnosis,vaccination,season,clinical characteristics and prognosis was analyzed.Results Of 3 068 suspected cases with pertussis,657 (21.4％) cases were clinically diagnosed as pertussis,of them,545 (83.0％) cases were diagnosed by pertussis serum antibody and/or PCR.247 (22.6％) cases aged from 0 to 3 months,199 (18.9％) aged from 3 months to 1 year,168 (19.8％) aged from 1 to 7 years,43 (58.1％) aged from 7 to 14 years.The diagnostic rate in children aged from 7 to 14 years was significantly higher than other children.The vaccination rate in children aged from 3 months to 1 year with pertussis or non-pertussis was 45.7％ (91/199) and 73.7％ (622/856),and the vaccination rate was 73.2％ (123/168) and 97.0％ (658/ 678) in children aged from 1 to 7 years.The vaccination rates between children aged from 7 to 14 years with pertussis and nonpertussis were similar (41/43 vs 29/31).PCR testing was positive in 545 cases (17.8％),of them,372 cases (12.1％) with positive serum antibody.The number of pertussis cases increased from May,with high level from July to September and decreased from October to December.Twenty-nine persons in the pertussis children family had clinical symptoms,of them 9 cases and their parents both with positive serum antibody or PCR results,6 children were clinically diagnosed with negative but whose parents with positive serum antibody or PCR results.Of 657 children with clinical diagnosis,215 (32.7％) had breathing,298 (45.4％) with fever.Six cases died from pertussis encepholopathy (3 cases),asphyxia (1 case),heart failure (1 case),persisting mechanical ventilation (1 case,gave up treatment).Conclusior Pertussis accounted for a large proportion of the children under 14 years with protracted cough in Jinan,especially in the children aged from 7 to 14 years.Pertussis showed a certain seasonal trend in Jinan.To protect the prevalence of pertussis,some measures should be taken including early vaccination 2 months after birth and revaccination for the preschool children.关键词
百日咳/流行特征/儿童Key words
Pertussis/Epidemiology/Children引用本文复制引用
韩玉玲,杨春,丁明杰,程璐,孙静,林美函,马香..济南市单中心迁延性咳嗽患儿中百日咳的横断面调查[J].中国循证儿科杂志,2016,11(3):200-203,4.
