中国药理学与毒理学杂志2017，Vol.31Issue(4)：346-351,6.DOI:10.3867/j.issn.1000-3002.2017.04.008
基于阿片受体亚型的药物研究进展
Research progress in drugs based on opioid receptor subtypes
摘要
Abstract
As classic analgesic drugs, opioids have received much attention in the medical area. With better clarified functions of opioid receptors, they are confirmed to mediate pain, addiction, emotion, and a variety of physiological and pathological activities. So far, opioid receptors have been divided in?to four subtypes including μ, δ, κ and ORL1 receptor. It has been proved that μ, δ and κ opioid receptor subtypes can induce different effects due to their own role and their distribution in the central nervous system. Based on the effect of opioid receptor subtypes, the development of specific drugs has become a new area in drug research. This paper summarizes research progress regarding those drugs, and developments are also predicted.关键词
阿片药物/阿片受体亚型/镇痛/二聚体Key words
opioids/opioid receptor subtype/analgesia/dimer分类
医药卫生引用本文复制引用
张晓琳,雍政,苏瑞斌..基于阿片受体亚型的药物研究进展[J].中国药理学与毒理学杂志,2017,31(4):346-351,6.基金项目
国家科技重大专项(2015ZX09501003)The project supported by National Science and Technology Major Project of China(2015ZX09501003) （2015ZX09501003）
