中国药理学与毒理学杂志2017，Vol.31Issue(4)：358-366,9.DOI:10.3867/j.issn.1000-3002.2017.04.010
G蛋白偶联受体在肝细胞癌中调控作用研究进展
Research progress in regulation roles of G protein-coupled receptors in hepatocellular carcinoma
摘要
Abstract
G protein- coupled receptors (GPCRs), also known as seven- transmembrane domain receptors, constitute the largest superfamily of cell surface receptors. By coupling to heterotrimeric G proteins, arrestins and other signaling molecules, GPCRs modulate diverse signal transduction pathways under physiological and pathological conditions. Recent studies have revealed crucial roles of GPCRs in tumorigenesis and development of cancer metastasis. This review summarizes roles of GPCRs, particularly the roles of those coupled to chemokines, prostaglandin, lysophosphatidic acid, endothelin, catecholamine and angiotensin in proliferation, invasion, metastasis and angiogenesis of hepatoma cells and development of hepatocellular carcinoma. The potential of GPCRs- based therapeutics being used for hepatocellular carcinoma is also highlighted.关键词
G蛋白偶联受体/肝细胞癌/趋化因子/溶血磷脂酸/肾上腺素受体/信号转导Key words
G protein coupled receptor/hepatocellular carcinoma/chemokines/lysophosphatidic acid/adrenergic receptor/signal transduction分类
医药卫生引用本文复制引用
彭文婷,孙妩弋,厉歆然,孙家昌,魏伟..G蛋白偶联受体在肝细胞癌中调控作用研究进展[J].中国药理学与毒理学杂志,2017,31(4):358-366,9.基金项目
国家自然科学基金(81300332) （81300332）
国家自然科学基金(813300810) （813300810）
国家自然科学基金(81673444) （81673444）
安徽省高等学校省级自然科学研究项目(KJ2012A153)The project supported by National Natural Science Foundation of China (81300332) （KJ2012A153）
National Natural Science Foundation of China (81330081) （81330081）
National Natural Science Foundation of China (81673444) （81673444）
and Natural Science Foundation of the Higher Education Institutions of Anhui Province (KJ2012A153) （KJ2012A153）
