摘要
Abstract
Objective To investigate the effects of Atorvastatin and Rosuvastatin on myocardial function and vascular endothelial function in patients with acute myocardial infarction. Method 98 patients with acute myocardial infarction in the Affiliated Hospital of Inner Mongolia Medical University from February 2014 to February 2015 were randomly divided into group A and group B, each group of 49 cases. All patients were given basic treatment, patients in group A were treated with Rosuvastatin, and patients in group B were treated with Atorvastatin. The levels of serum lipids, high sensitive C reactive protein (hs-CRP), vascular endothelial function and cardiac function were compared between the two groups before and after treatment. Followed up for 1.5 years, the incidence of adverse cardiovascular events was compared between the two groups. Result After treatment, there were no significant differences in the ejection fraction (EF), mitral orifice blood flow velocity (MV), tricuspid orifice blood flow velocity (TV), aortic valve blood flow velocity (AV) between the two groups (P > 0.05), but EF, MV, TV, AV of the two groups were higher than those before treatment (P < 0.05). After treatment totalcholesterol (TC), low density lipoprotein (LDL) and hs-CRP levels of the two groups were lower than those before treatment (P < 0.05); after treatment, TC, LDL and hs-CRP levels of group A were significantly lower than those of group B (P < 0.05), high density lipoprotein (HDL) of group A was significantly higher than that in group B (P < 0.05). There were no deaths during the follow-up period between the two groups, 2 patients with recurrent angina pectoris and 3 patients with poor revascularization in group A, the incidence of cardiovascular events was 10.20% (5/49). 3 patients with recurrent angina pectoris and 4 patients with poor revascularization in group B, the incidence of cardiovascular events was 14.29% (7/49), there was no significant difference in the incidence of adverse events between the two groups (P > 0.05). Conclusion Rosuvastatin can improve cardiovascular function in patients with acute myocardial infarction better than Atorvastatin.关键词
阿托伐他汀/瑞舒伐他汀/急性心肌梗死/血管内皮功能Key words
Atorvastatin/Rosuvastatin/Acute myocardial infarction/Vascular endothelial function
