中华骨质疏松和骨矿盐疾病杂志2017，Vol.10Issue(2)：104-109,6.DOI:10.3969/j.issn.1674-2591.2017.02.002
胸、腰椎骨质疏松性骨折患者椎体骨铁含量、血清铁蛋白与骨密度的相关性
Correlation among bone iron content,serum ferritin and bone mineral densityin patients with thoracolumbar fractures
摘要
Abstract
Objective To explore the association among bone iron content,serum ferritin(SF) and bone mineral density in patients with thoracolumbar fractures.Methods A retrospective analysis was conducted in 243 patients with thoracotumbar fracture who were undergone percutaneous kyphoplasty from January 2008 to December 2014.Mean age of the patients(91 males and 152 females)was 62.5 years(range:50-81 years).The patients were assigned to osteopenia group and osteoporosis group based on the preoperative bone mineral density(BMD).Blood samples were collected to determine iron metabolism and bone turnover biomarkers after overnight fasting.Bone specimens were obtained for detecting bone iron contents and performing iron stain respectively after percutaneous kyphoplasty.Results There was no significant statistical significance between osteopenia group and osteoporosis group in gender,age,height, and weight(P>0.05).Pearson correlation analysis showed that the age,bone iron content,SF,serum procollagen type 1 N-terminal propeptide, and β-carboxy terminal telopeptide of collagen type 1 were negatively correlated with BMD at femoral neck (r=-0.712,-0.348、-0.323,-0.236,-0.227;all P<0.05) and lumbar spine (r=-0.541,-0.206,-0.213,-0.184,-0.191;all P<0.05);the weight,body mass index,transferrin, and total iron binding capacity were positively correlated with BMD at femoral neck and lumbar spine (P<0.05).Bone iron content combined with SF could be put into the regression models of BMD at femoral neck and lumbar spine(femoral neck R2=0.388,L1-4 R2=0.374).Both bone iron content and SF were negatively correlated with BMD at lumbar spine (P<0.05).Conclusion The higher the values of bone iron and serum iron protein content in osteoporotic vertebral fracture patients,the higher the degree in osteoporosisis.Iron accumulation and osteoporosis is significantly correlated.关键词
骨质疏松/椎体骨折/骨密度/铁蛋白Key words
osteoporosis/vertebral fractures/bone mineral density/ferritins分类
医药卫生引用本文复制引用
刘栋,孙永明,华俊,林凡国,苏朋,曹录民,王登峰,吴涛,牛延平..胸、腰椎骨质疏松性骨折患者椎体骨铁含量、血清铁蛋白与骨密度的相关性[J].中华骨质疏松和骨矿盐疾病杂志,2017,10(2):104-109,6.基金项目
苏州市科教兴卫青年项目基金(kjxw2014062) （kjxw2014062）
