中成药2017，Vol.39Issue(4)：665-671,7.DOI:10.3969/j.issn.1001-1528.2017.04.001
内异康复片调控GPER-Ras-STAT3通路治疗子宫腺肌病的机制
Mechanism of Neiyi Kangfu Tablets in treatment of adenomyosis through regulating GPER-Ras-STAT3 signal pathway
摘要
Abstract
AIM To study the therapeutic effects of Neiyi Kangfu Tablets (Trionycis Carapax,Ostreae concha,Rhei Radix et Rhizoma,etc.) on adenomyosis and its possible mechanism of action.METHODS The mouse model for adenomyosis was set up by the pituitary allograft,and received the gavage of Neiyi Kangfu Tablets,Dan'e Fukang Decoction (Salviae miltiorrhizae Radix et Rhizoma,Curcumae Rhizoma,Paeoniae Radix rubra,etc.) and gestrinone,respectively,for three months.Western blot,real-time PCR,IHC were used to measure the expression of GPER-Ras-STAT3 in ectopic endometrium and entopic endometrium.RESULTS High doses of Neiyi Kangfu Tablets could significantly lower GPER protein and gene expression;down-regulate the Ras and STAT3 protein expression;reduce the lesion severity score of ectopic tissue morphology.Its curative effect was better than Dan'e Fukang Decoction and gestrinone.CONCLUSION Neiyi Kangfu Tablets may control the development of ectopic lesions by inhibiting the GPER-Ras-STAT3 pathway activity and weakening the production of estrogen.关键词
子宫腺肌病/内异康复片/GPER-Ras-STAT3通路/作用机制Key words
adenomyosis/Neiyi Kangfu Tablets/GPER-Ras-STAT3 pathway/mechanism分类
医药卫生引用本文复制引用
冯婷婷,王烨,屈丽媛,范小雪,曾美玲,魏绍斌..内异康复片调控GPER-Ras-STAT3通路治疗子宫腺肌病的机制[J].中成药,2017,39(4):665-671,7.基金项目
国家自然基金项目(81273796) （81273796）
