中成药2017，Vol.39Issue(4)：672-676,5.DOI:10.3969/j.issn.1001-1528.2017.04.002
精杞胶囊对大鼠生精功能损伤的保护作用
Protective effects of Jingqi Capsules on damage to rat reproductive system
摘要
Abstract
AIM To study the protective effects of Jingqi Capsules (Cordycps Militaris,Rehmanniae Radix Praeparata,Lycii Fructus,) on the damage to rat reproductive system induced by cyclophosphamide.METHODS After low and high dose groups of Jingqi Capsules and positive group were administered for two weeks in advance,cyclophosphamide [25 mg/(kg · d)] modeling was conducted consecutively by intraperitoneal injection for five days except the normal group,while the treatment groups were administered consecutively.All the rats were executed the day after the end of the modeling.Serum testosterone content was measured by radioimmunoassay;body weight,testis,epididymis and prostate of rats were weighed and organ coefficient was calculated;morphology of testis was observed by HE;sperm count and sperm motility were detected by CASA;apoptosis of cells was observed by TUNEL.RESULTS Compared with the model group,each dose group of Jingqi Capsules increased in the level of serum testosterone and organ coefficient of testis,epididymis and prostate.The damage to seminiferous epithelium relieved and the number of all spermatogenic cells increased.Sperm count and sperm motility increased.Decrease in apoptosis of cells was demonstrated by TUNEL.CONCLUSION Jingqi Capsules has protective effects on damage to rat reproductive system induced by cyclophosphamide.关键词
精杞胶囊/环磷酰胺/生殖损伤保护/生精功能Key words
Jingqi Capsules/cyclophosphamide/reproductive damage protect/spermatogenesis分类
医药卫生引用本文复制引用
万芳,马红,吕晔,韦敏..精杞胶囊对大鼠生精功能损伤的保护作用[J].中成药,2017,39(4):672-676,5.基金项目
江苏省高校优势学科建设工程一期项目(YS2012ZYX304) （YS2012ZYX304）
