中成药2017，Vol.39Issue(4)：695-700,6.DOI:10.3969/j.issn.1001-1528.2017.04.006
坤泰胶囊对VCD所致POI模型大鼠的疗效探究
Curative effect of Kuntai Capsules on POI rats induced by VCD
摘要
Abstract
AIM To investigate the curative effects of Kuntai Capsules (Coptidis Rhizoma,Scutellariae Radix,Asini Corii Colla,etc.) on rat model for primary ovarian insufficiency (POI) caused by 4-vinylcyclohexene diepoxide (VCD).METHODS Seventy-five weaned 21-day old rats were divided equally into five groups randomly:control group,model group,low-,medium-,and high-dosage Kuntain group.Except the control group was given sesame oil rats,other four groups were given intraperitoneal injection of VCD solution.According to vaginal smear of rats,eight rats in each group were selected,the levels of FSH (follicle-stimulating hormone),LH (leuteinizing hormone),E2 (estradiol) and AMH (anti-Mullerian hormone) were measured,and morphological changes of ovary and uterus were observed.RESULTS Compared to the control group,FSH level in rats' serum of the model group significantly increased while AMH and E2 levels significantly decreased,and LH level rose;Kuntai Capsules significantly decreased FSH level while increased AMH level;The wet weight of rats' ovary in the model group was lighter than that in the control group.The ovary weight of Kuntai Capsules low-dosage group was increased;the number of follicles at all levels and corpora lutea of rats in the model group were decreased.After the treatment with Kuntai Capsules,the number of follicles at all levels and corpora lutea were increased;light microscopy manifested decreased uterine glands of the tube wall,reduced glandular cavity.After the treatment with Kuntai Capsules,the number of uterine glands increased and the gland cavity expanded.CONCLUSION Kuntai Capsules may slowdown the functional decline rate of ovarian.关键词
坤泰胶囊/卵巢功能不全(POI)/去氧乙烯基环乙烯(VCD)Key words
Kuntai Capsules/primary ovarian insufficiency (POI)/4-vinylcyclohexene diepoxide (VCD)分类
医药卫生引用本文复制引用
周蓓蓓,陈文俊,谈勇..坤泰胶囊对VCD所致POI模型大鼠的疗效探究[J].中成药,2017,39(4):695-700,6.基金项目
江苏省科技计划项目临床医学科技专项(BL2013039) （BL2013039）
横向课题,和颜坤泰胶囊对VCD所致大鼠卵巢功能损伤动物模型的保护作用研究(2015026) （2015026）
