中成药2017，Vol.39Issue(4)：701-705,5.DOI:10.3969/j.issn.1001-1528.2017.04.007
滇龙胆不同部位提取物保肝抗炎作用的研究
Liver-protective and anti-inflammatory effects of extracts from different parts of Gentiana rigescens
摘要
Abstract
AIM To compare liver-protective and anti-inflammatory effects of extracts from root,stem,leaf,and flower of Gentiana rigescens.METHODS The mouse model for the immunological liver injury induced by Concanavalin A,and mouse ear swelling model for inflammation caused by dimethylbenzene were used for the comparison of the liver-protective or anti-inflammatory effects of four parts individually.RESULTS Four aqueous extracts of Gentiana rigescens showed the dose-dependent decrease in the activity of ALT and AST in serum and liver index,and alleviation of hepatic tissue injury induced by Concanavalin A in mice.The effects of the extracts from the leaf and root were better than those from the stem and flower.These extracts presented dose-dependent inhibition against the ear swelling caused by dimethylbenzene in mice.The effects of the extracts from the leaf and stem were better than those from the flower and root.CONCLUSION Extracts from the root and leaf of G.rigescens have liver-protective effect,and parts from the stem and leaf have anti-inflammatory effect.关键词
滇龙胆/根/茎/叶/花/刀豆蛋白A/二甲苯/保肝抗炎Key words
Gentiana rigescens/root/stem/leaf/flower/concanavalin A/dimethylbenzene/liver-protective and anti-inflammatory effects分类
医药卫生引用本文复制引用
沈磊,谢文菠,王修波,张延婷,李会仙,李海峰,白丽..滇龙胆不同部位提取物保肝抗炎作用的研究[J].中成药,2017,39(4):701-705,5.基金项目
国家自然科学基金项目(81102806) （81102806）
大理大学博士基金项目(KYBS201411) （KYBS201411）
云南省教学质量与教学改革工程资助项目(云教高,2010,105号) （云教高,2010,105号）
