中成药2017，Vol.39Issue(4)：706-710,5.DOI:10.3969/j.issn.1001-1528.2017.04.008
红花黄色素治疗严重脓毒症患者的心肌损伤
Safflower yellow treats the myocardial injury in patients with severe sepsis
摘要
Abstract
AIM To investigate the effects of safflower yellow on myocardial injury in patients with severe sepsis.METHODS Using prospective research methods,ninety-two patients with severe sepsis treated in our hospital from Jan.2013 to Mar.2016 were divided equally into two groups:control group (routine treatment) and observation group (routine treatment + safflower yellow).In addition,6 and 72 hours after the treatment,heart-type fatty acid binding protein (H-FABP),creatine kinase (CK) and creatine kinase isoenzyme (CK-MB) of patients were detected,and the changes of left ventricular ejection fraction (LVEF) and sequential organ failure assessment (SOFA) scores were observed;length of ICU stay,cumulative incidence of major adverse cardiac events (MACE) and 28-day survival also were recorded at the same time.RESULTS In admission,there were no differences in the levels of H-FABP,CK,CK-MB and LVEF,SOFA scores between the two groups.After 6 hours treatment,the levels of H-FABP,CK,CK-MB and SOFA score in the observation group were lower than those in the control group;the two groups had higher levels of H-FABP,CK and CK-MB than those before the treatment,SOFA score was lower than that before the treatment;After 72 hours treatment,H-FABP,CK,CK-MB and SOFA score were lower than those after 6 hours treatment;SOFA score in the observation group was lower than that in the control group;there were no differences in H-FABP,CK and CK-MB between the two groups.The observation group had a lower cumulative incidence of MACE than the control group.There was no statistical difference in LVEF and length of ICU stay after the treatment between the two groups.The observation group had a higher 28-day survival than the control group,the difference was statistically significant (76.08％,35/46 vs 54.35％,25/46;x2 =4.529,P =0.033).The level of serum H-FABP in severe sepsis patients was negatively correlated with LVEF (r =-0.270,P =0.009).CONCLUSION Therapeutic effects of safflower yellow on myocardial injury in patients with severe sepsis is superior to routine treatment with the improvement of the prognosis of patients to a certain extent.关键词
红花黄色素/严重脓毒症/心肌损伤/心型脂肪酸结合蛋白/序贯器官功能衰竭评分/主要心脏不良事件Key words
safflower yellow/severe sepsis/myocardium injury/heart-type fatty acid binding protein/sequential organ failure assessment/major adverse cardiac events分类
医药卫生引用本文复制引用
褚永果,齐洪娜,刘晓婷,何佳起,张建军,王维展..红花黄色素治疗严重脓毒症患者的心肌损伤[J].中成药,2017,39(4):706-710,5.基金项目
衡水市科学技术研究与发展计划项目(15019) （15019）
