中国现代中药2016，Vol.18Issue(9)：1114-1119,6.DOI:10.13313/j.issn.1673-4890.2016.9.007
茜草炭抗雌二醇致大鼠出血倾向的活性部位研究
Study on Active Parts from Rubiae Radix et Rhizoma (carbonized) in Rats with Estradiol Induced Bleeding Tendency
摘要
Abstract
Objective:To diseuss the hemostasis of the different polarities of Rubiae Radix et Rhizoma (carbonized) on the dysfunctional uterine bleeding rat model.Methods:The SD rats were divided into seven groups.The rats in the control group were fed with CMC-Na for 3 weeks,the other groups were fed with estradiol valerate for 3 weeks.Gong Xue Ning was taken as the positive control drug.The rats in the control group and model group were fed with CMC-Na for 7 days,and the rats in other groups were fed with corresponding drugs simultaneously.The influence of the different polarities of carbonized Rubia cordifolia compound to dyfunctional uterine bleeding (DUB) rat’s hemorheology,coagulation system,fibrinolytic system,tissue morphology and platelet system.Results:Compared with the control group,the model group could reduce the whole blood viscosity in each shear rate (P ＜0.01) and prolong the TT,PT,APTT (P ＜ 0.05,P ＜ 0.01),increase the FIB,6-keto-PGF1α content and ADP％ (P ＜ 0.01),and decrease the TXB2.Compared with the model group,ethyl acetate and butanol extract group could increase the whole b--lood viscosity in each shear rates (P ＜ 0.05,P ＜ 0.01),shorten the TT,PT,APTT (P＜0.05,P＜0.01),decrease the content of FIB,6-keto-PGF1α and ADP％ (P＜0.05,P＜0.01),and increase the TXB2,while petroleum ether and water extract groups gave no significant effect.Conclusion:Ethyl acetate extract is the active part of Rubiae Radix et Rhizoma (carbonized),showing the effect of hemostasis by reducing the low whole blood viscosity,improving coagulation function mainly and ameliorating the function of platelet aggregation.关键词
茜草炭/止血/子宫出血/有效部位Key words
Rubiae Radix et Rhizoma (carbonized)/hemostasis/dysfunctional uterine bleeding/active parts引用本文复制引用
薛露,王海丽,肖林焱,陈毅,单鸣秋,张丽,丁安伟..茜草炭抗雌二醇致大鼠出血倾向的活性部位研究[J].中国现代中药,2016,18(9):1114-1119,6.基金项目
国家自然科学基金(81473348) （81473348）
江苏高校优势学科建设工程资助项目(ysxk-2014) （ysxk-2014）
江苏高校品牌专业建设工程资助项目(PPZY2015A070) （PPZY2015A070）
