中国现代中药2016，Vol.18Issue(9)：1192-1195,4.DOI:10.13313/j.issn.1673-4890.2016.9.024
正交试验法优选复方白芍肠康颗粒提取工艺
Optimization of Extraction Technology for Fufang Baishaochangkang Granules by Orthogonal Design
陈锋 1严常开 2张进2
作者信息
- 1. 湖北中医药大学药学院,湖北 武汉430065
- 2. 马应龙药业集团股份有限公司,湖北 武汉430064
- 折叠
摘要
Abstract
Objective:To optimize extraction technology of Fufang Baishaochangkang Granules.Methods:Taking content of paeoniflorin and dry extract rate as evaluation index,orthogonal test was employed to investigate effects of the amount of water,extraction time and times on water extraction process.With contents of magnolol and dry extract rate as evaluation index,orthogonal test was adopted to optimize ethanol extraction process with ethanol concentration,ethanol amount,extraction time and times.Content of paeoniflorin and magnolol were determined by HPLC.Results:Optimum water extraction conditions were as follows:decocted twice with 10 times the volume of water 1.5 h per time.Extracting amount of paeoniflurin was 24.28 mg·g-1,dry extract rate was 34.05％.Optimal alcohol extraction conditions were as follows:extracted twice with 8 times the amount of 60％ ethanol for 1.5h each time;Extracting amount of magnolol was 11.14 mg·g-1,dry extract rate was 19.71％.Conclusion:The optimized extraction process was stable and feasible which could provide a reference for rational development of Fufang Baishaoc hangkang Granules.关键词
芍药苷/厚朴酚/复方白芍肠康颗粒/溃疡性结肠炎/正交试验/提取工艺Key words
Paeoniflorin/magnolol/Fufang Baishaochangkang Granules/ulcerative colitis/orthogonal design/extraction process引用本文复制引用
陈锋,严常开,张进..正交试验法优选复方白芍肠康颗粒提取工艺[J].中国现代中药,2016,18(9):1192-1195,4.
