安徽农业科学2017，Vol.45Issue(10)：104-105,112,3.
西地碘粉的急性毒性研究
Study on the Acute Toxicity of Cydiodine Powder
摘要
Abstract
[Objective] To study the oral acute toxicity of cydiodine powder on mice.[Method] 60 clean-level ICR mice were selected to make acute toxicity test by using Korbor method.The acute toxicity symptoms of cydiodine powder on mice were observed, and its LD50 on mice by oral administration was determined.[Result]The acute toxicity symptoms of cydiodine powder on mice were as follows: after drug administration 15 min, mice in high-dose group had depressed spirit, disordered clothing hair, slow response, paralysis and loss of appetite;After drug administration 0.5-1.0 h, mice had difficult breathing, accompanied by straight neck and loss of appetite;After drug administration 3 h, mice began to die and eclampsia, convulsion, tremor and other neural symptoms appeared before the death of mice.And the acute death occurred after drug administration 3-24 h.It was observed through autopsy that the main manifestation of poisoning symptoms was the damage to liver, followed by the damage to lung and heart.According to the death rate in each dose group, the acute oral LD50 of cydiodine powder on mice was 4 972.75 mg/kg, 95% confidence limit of LD50 was 4 382.77-5 642.16 mg/kg.[Conclusion]The oral LD50 of cydiodine powder on mice was between 501-5 000 mg/kg, belonging to low-toxicity drug.关键词
西地碘粉/小鼠/LD50Key words
Cydiodine powder/Mice/LD50分类
农业科技引用本文复制引用
李桂明,李颖,宋敏训,林树乾,杨世发,傅剑,赵增成,黄中利,冯敏燕,逯月,商晶..西地碘粉的急性毒性研究[J].安徽农业科学,2017,45(10):104-105,112,3.基金项目
农业部公益性行业(农业)科研专项(201303038-10) （农业）
济南市明星计划项目(201406024) （201406024）
山东省农业科学院青年基金项目(2015YQN59) （2015YQN59）
山东省现代农业产业技术体系项目(SDAIT-13-011-01). （SDAIT-13-011-01）
