广东医学2017，Vol.38Issue(5)：672-674,3.
富氢生理盐水对大鼠痛风性关节炎的保护作用
Study on the effect of hydrogen rich saline on gout arthritis in rats
招友 1樊彦伟 2马广斌 2严冬雪2
作者信息
- 1. 河池市人民医院骨科,广西河池547000
- 2. 桂林医学院附属医院骨科,广西桂林541001
- 折叠
摘要
Abstract
Objective To investigate the protective effects of hydrogen rich saline on acute gouty arthritis model in rats.Methods Forty rats were randomly divided into four groups,control group,model group,hydrogen rich saline group and colchicine group.In colchicine group,0.3 mg/kg colchicine were given with lavage;10 mL hydrogen rich saline were also given in hydrogen rich saline group continuously for 4 weeks.The control group and the model group were given with the same volume of Twain-saline.Acute gouty arthritis model was established at the last time after pretreatment.The acute gouty arthritis models were established on the last time after intragastric administration,by the method of intraarticular injection of sodium urate.The subject joint circumference,interleukin-1 β (IL-1 β) and tumor necrosis factor-α (TNF-α) were measured before and after model establishment.The joint soft tissues were collected for histopathology examination.Besides,combine the behaviors of rats to evaluate the therapeutic effect.Results Compared to the model group,significant improvement in joint circumference,gait,serum IL-1 β and TNF-α and the inflammatory reaction of subject ankle joint were revealed in colchicine group and hydrogen rich saline group colchicine group.Conclusion Hydrogen rich saline can reduce the inflammatory reaction and also effectively inhibit the gout arthritis in rats.关键词
痛风性关节炎/富氢生理盐水/白细胞介素-1β/肿瘤坏死因子-αKey words
gout arthritis/hydrogen rich saline/interleukin-1 β/tumor necrosis factor-α引用本文复制引用
招友,樊彦伟,马广斌,严冬雪..富氢生理盐水对大鼠痛风性关节炎的保护作用[J].广东医学,2017,38(5):672-674,3.
