国际医药卫生导报2017，Vol.23Issue(7)：955-957,971,4.DOI:10.3760/cma.j.issn.1007-1245.2017.07.008
加减知柏地黄丸对特发性中枢性性早熟患者骨相关指标的影响
Effect of modified Zhibai Dihuang pills on bone related indicators in patients with idiopathic central precocious puberty
摘要
Abstract
Objective To investigate the law of bone related indicators in and the effect of modified Zhibai Dihuang pills for girls with idiopathic central precocious puberty.Methods The contents N-MID osteocalcin fragments (N-MID OCT),Procollagen propeptide of type Ⅲ procollagen (PⅢNP) and ghrelin (Ghrelin) in precocious girls with different ages were detected to explore the regularity of skeletal dysplasia in the children.Among which,60 cases were randomly divided into 2 groups.There were no statistical differences between the two groups.The treatment was treated with modified Zhibai Dihuang pills and the control group leuprorelin.The bone related indicators were observed after disease remission.Results There were no statistical differences between the treatment group and the control group before and after the treatment (P ＞ 0.05).Before the treatment,in the treatment group,the N-MID OCT,PⅢNP,and Ghrelin were (110.51± 11.16),(31.73±0.30),and (2.73±0.04);six months after the treatment,the N-MID OCT and PⅢNP were (92.22±3.80) and (29.46±0.88),with statitstical differences (all P ＜ 0.01),and the Ghrelin was (2.74±0.03),with no statistical difference (P ＞ 0.05);one year the treatment,the N-MID OCT and PⅢNP decreased to (61.49±4.64) and (23.14±1.47) and the Ghrelin increased to (2.86±0.03),with statistical differences (all P ＜ 0.01).Conclusion Modified Zhibai Dihuang pills can change the bone related indicators,N-MID OCT,PⅢNP,and Ghrelin,in children with ICPP and inhibit osteoblast hyperfunction activity.关键词
特发性中枢性性早熟/加减知柏地黄丸/骨相关指标Key words
Idiopathic central precocious puberty/Modified Zhibai Dihuang pills/Bone related indicators引用本文复制引用
黄桢,曾博煌,朱秀梅,张泳,卢靖怡,王修银..加减知柏地黄丸对特发性中枢性性早熟患者骨相关指标的影响[J].国际医药卫生导报,2017,23(7):955-957,971,4.基金项目
广州市中医药和中西医结合科技项目(20152A011014)Traditional Chinese Medicine and Integrated Traditional and Western Medicine Science and Technology Projects of Guangzhou City (20152A011014) （20152A011014）
