国际生殖健康/计划生育杂志2017，Vol.36Issue(2)：156-159,4.
肝素结合性表皮生长因子在生殖医学中的研究进展
Research Progress of Heparin-binding Epithelial Growth Factor in Reproductive Medicine
周一鸣 1汤小晗1
作者信息
- 1. 150001 哈尔滨医科大学附属第一医院生殖医学中心
- 折叠
摘要
Abstract
Heparin-binding epithelial growth factor (HB-EGF),a member of the EGF family,is synthesized as a membrane-anchored precursor (proHB-EGF).ProHB-EGF is then cleaved to yield a soluble HB-EGF (sHB-EGF) by specific metalloproteases.ProHB-EGF is not only the precursor molecule for sHB-EGF but also a biologically active molecule itself.ProHB-EGF forms a complex with membrane proteins,which is localized at the cell contact site,suggesting that proHB-EGF may function in cell-to-cell signaling by a juxtacrine mechanism.In an in vitro model,proHB-EGF showed a growth inhibitory activity while sHB-EGF a growth stimulatory activity,suggesting that proHB-EGF and sHB-EGF work in different ways.However,the in vivo functions of sHB-EGF and proHB-EGF have not been defined.Many recent studies suggested that they play an important role in various physiological processes.This review introduced the potential roles of HB-EGF in reproductive endocrine,including mitosis and apoptosis of the corpus lutein cells,follicular development and embryo transfer.关键词
肝素结合性表皮生长因子/表皮生长因子/肝素/黄体细胞/卵泡/胚胎移植/生殖医学Key words
Heparin-binding EGF-like growth factor/Epidermal growth factor/Heparin/Luteal cells/Ovarian follicle/Embryo transfer/Reproductive medicine引用本文复制引用
周一鸣,汤小晗..肝素结合性表皮生长因子在生殖医学中的研究进展[J].国际生殖健康/计划生育杂志,2017,36(2):156-159,4.
