临床与病理杂志2017，Vol.37Issue(2)：227-232,6.DOI:10.3978/j.issn.2095-6959.2017.02.002
ATM基因rs227060位点单核苷酸多态性与肺癌易感性的相关性
Association between single nucleotide polymorphisms of rs227060 site in ATM gene and lung cancer susceptibility
摘要
Abstract
Objective:To explore the correlation between the single nucleotide polymorphism (SNP) of rs227060 site in ATM gene and lung cancer susceptibility.Methods:A total of 225 lung cancer cases and 128 healthy normal control people were recruited into current study.The allele and the distribution frequency of genotype at the polymorphism of rs227060 loci in ATM gene was detected by PCR-On/Off Switch technique in all patients.The correlation between ATM rs227060 loci and lung cancer was analyzed with unconditional Logistic regression analysis.Results:Three genotypes,CC,CT,TT,and two alleles,C,T,were detected in the polymorphism allele of rs227060 loci,the distribution frequency of the genotype in lung cancer group and control group were CC (17.3％ and 29.7％),CT (61.3％ and 59.3％),TT (21.4％ and 11％),the differences of the frequency of genotype and allele between two groups were not statistically significant (P＜0.05).During the analysis of the polymorphism of ATM rs227060 genotype,the difference in smoking history was not statistically significant between the two groups (P＞0.05),but in age,gender,family history of malignancy it was statistically different between the two groups (P＜0.05).Compared with genotype CC,TT genotype increased the risk of lung cancer by 3.49 times than CT genotype (OR =1.829;95％CI:1.045-3.199).Conclusion:There was an association between the SNP of rs227060 site in ATM gene and lung cancer susceptibility,and carrying the TT genotype may increase the risk of lung cancer.关键词
肺癌易感性/单核苷酸多态性/ATM基因/SNP敏感性分子开关Key words
lung cancer susceptibility/gene polymorphism/ATM gene/PCR-On/Off Switch引用本文复制引用
彭华,董巍檑,龚咏晴,周晶,郭紫芬..ATM基因rs227060位点单核苷酸多态性与肺癌易感性的相关性[J].临床与病理杂志,2017,37(2):227-232,6.基金项目
国家自然科学基金(81102516) （81102516）
南华大学大学生研究生科研创新项目(2016XCXC36). This work was supported by the National Natural Science Foundation of China (81102516) and the Graduate Students Scientific Research Innovation Projects of University of South China (2016XCXC36),P.R.China. （2016XCXC36）
