临床与病理杂志2017，Vol.37Issue(2)：233-240,8.DOI:10.3978/j.issn.2095-6959.2017.02.003
三阴性乳腺癌患者BRCA1和BRCA2基因突变的临床特征及预后因素
Clinical features and prognostic factors of BRCAI and BRCA2 gene mutations in patients with triple-negative breast cancer
摘要
Abstract
Objective:To investigate the clinical features and prognostic factors of BRCA1 and BRCA2 gene in patients with triple-negative breast cancer.Methods:A total of 156 triple-negative breast cancer patients were selected from Jan.2003 to Dec.2015.All patients were tested for BRCA1 and BRCA2 mutations by PCR and DNA sequencing.Characteristics of BRCA1 and BRCA2 gene mutations in patients with breast cancer were analyzed retrospectively.Log-Rank test was applied for single factor analysis of BRCA1 and/or BRCA2 gene mutations breast cancer patients,such as age,ECOG state,clinical stage,lymph node number,menstrual status and drugdelivery way.Cox risk proportional regression model was used for multiple-factor analysis such as the patient's age,ECOG state,clinical stage,positive number of lymph nodes,tumor size,menstrual status and drug delivery,etc.Results:Gene mutation occurred in 21 triple-negative breast cancer patients,the overall incidence was 13.46％,15 cases of BRCA1 mutation,6 cases of BRCA2 mutation.Log-Rank test results showed that the older the age of onset,the more late clinical stage,the higher the ECOG score,the more positive number of lymph nodes,the worse the prognosis (P＜0.05);and the incidence of menstrual status and drug delivery methods do not correlated with prognosis.Cox proportional hazards regression model showed that tumor size (relative risk,3.163;95％ CI:1.455-9.287;P＜0.05) and the number of lymph node metastasis (relative risk,1.859;95％ CI:1.254-6.875;P＜0.05) is the independent prognostic factors of prognosis of BRCA gene mutations in triple-negative breast cancer.Conclusion:The mutation of BRCA1 and BRCA2 genes may be closely related to breast cancer,especially triple-negative breast cancer.The onset age,ECOG score,clinical stage,positive number of lymph nodes,tumor size were related to the prognosis ofBRCA gene mutations in triple-negative breast cancer.关键词
三阴乳腺癌/BRCA1/BRCA2/基因突变/预后因素Key words
triple-negative breast cancer/BRCA1/BRCA2/gene mutation/prognosis引用本文复制引用
黄志坚,林庆中,黄秋艳,肖晨,陈夏,许春伟,方美玉..三阴性乳腺癌患者BRCA1和BRCA2基因突变的临床特征及预后因素[J].临床与病理杂志,2017,37(2):233-240,8.基金项目
国家临床重点专科建设项目(2013),福建中医药大学校管科研课题(XB2016060). This work was supported by National Clinical Key Specialty Construction Program (2013),Fujian University of Traditional Chinese Medicine Scientific Research Subject (XB2016060),P.R.China. （2013）
