埃克替尼对非小细胞肺癌EGFR 20外显子突变的临床疗效分析
Clinical efficacy of icotinib in patients with advanced non-small cell lung cancer harboring EGFR exon 20 mutations
摘要
Abstract
Objective:To investigate the efficacy of icotinib in patients with non-small cell lung cancer (NSCLC) that carrying S768I/20 insertions/T790M/V769M in EGFR exon 20.Methods:Fifty eight cases of EGFR 20 exon rare mutation NSCLC patients were retrospectively analyzed until the progress of the disease or the emergence of the side effects and clinical efficacy was observed after months of followed-up.Results:Fifty eight patients with S768I/20 insertion/T790M/V769M mutations were enrolled.Mutations including S768I,exon 20 insertions,T790M and V769M mutations were observed in 20,18,21 and 1 patients,respectively.Patients with S768I mutation or V769M mutation manifested the longest median PFS (3.2 months),followed by those with T790M (1.6 months) and exon 20 insertions (1.9 months).Patients with complex mutations showed a better PFS than those with single mutations (S768I mutations 2.2 vs.3.3 months,P=0.174;T790M 2.45 vs.2.9 months,P=0.845).Conclusion:Icotinib is less effective in patients with exon 20 uncommon mutations than in those with common mutations.Patients with complex mutations benefited more from icotinib than those with single mutations.关键词
非小细胞肺癌/埃克替尼/20外显子Key words
non-small cell lung cancer/icotinib/exon 20引用本文复制引用
庄武,林贤东,许春伟,陈刚,陈燕坪,黄韵坚,黄章洲,朱有才,杜开齐,方美玉,王晓江,师怡..埃克替尼对非小细胞肺癌EGFR 20外显子突变的临床疗效分析[J].临床与病理杂志,2017,37(2):282-288,7.基金项目
国家临床重点专科建设项目(2013) （2013）
福建省科技厅引导性项目(2016Y0019) （2016Y0019）
福建省科技厅引导性项目(2015Y0011) （2015Y0011）
浙江省卫生科研计划基金(2013KYB051) （2013KYB051）
浙江省中医药局科研基金(2013ZQ005) （2013ZQ005）
浙江省科技厅公益类科研计划(2015C33194).This work was supported by National Clinical Key Specialty Construction Program (2013) （2015C33194）
Leading Project Foundation of Science Department of Fujian Province (2016Y0019) （2016Y0019）
Leading Project Foundation of Science Department of Fujian Province (2015Y0011) （2015Y0011）
Medical Scientific Research Foundation of Zhejiang Province of China (2013KYB051) （2013KYB051）
Zhejiang Administration of Traditional Chinese Medicine Foundation (2013ZQ005) （2013ZQ005）
The Science and Technology Planning Project of Zhejiang Province of China (2015C33194). （2015C33194）
