国际病理科学与临床杂志2017，Vol.37Issue(2)：315-318,4.DOI:10.3978/j.issn.2095-6959.2017.02.016
D-二聚体联合纤维蛋白原对2型糖尿病患者急性肺栓塞的诊断价值
Diagnostic value of D-dimer and fibrinogen for type 2 diabetes mellitus with acute pulmonary embolism
顿晓熠 1刘志英 1吴勤奋2
作者信息
- 1. 解放军第474医院内分泌科,乌鲁木齐830013
- 2. 解放军第474医院神经科,乌鲁木齐830013
- 折叠
摘要
Abstract
Objective:To evaluate the diagnostic value of D-dimer (D-D) and fibrinogen (FIB) testing for diagnosis of type 2 diabetes mellitus with acute pulmonary embolism (APE).Methods:A total of 160 patients with type 2 diabetes in Department of Endocrinology in our hospital from January 2013 to March 2016 were selected and divided into APE group (n=80) and non-APE group (n=80) according to computed tomographic pulmonary angiography (CTPA).Plasma level of D-D and FIB in each patient was detected.Results:The concentrations of D-D and FIB in APE group were higher than those in non-APE group.The sensitivity,specificity,Youden index and the area under curve (AUC) of the ROC curve of D-D and FIB were 72.5％,42.5％;62.5％,91.25％;0.35,0.338;0.675 (95％CI:0.597-0.747),0.669 (95％ CI:0.590-0.741);respectively.In combined assay of D-D and FIB to test APE,the sensitivity,specificity,Youden index and the AUC of the ROC curve was 85.0％,60.0％,0.45,0.773 (95％ CI:0.700-0.835).The area under the ROC curve of the combined assay of D-D and FIB was higher compared with the solo assay of D-D or FIB for testing APE,there was a significant difference (P＜0.01).Conclusion:T-he combined assay of D-D and FIB has significantly clinical value and can be used in diagnosis of APE in type 2 diabetes mellitus patients.关键词
2型糖尿病/急性肺栓塞/D-二聚体/纤维蛋白原Key words
type 2 diabetes mellitus/acute pulmonary embolism/D-dimer/fibrinogen引用本文复制引用
顿晓熠,刘志英,吴勤奋..D-二聚体联合纤维蛋白原对2型糖尿病患者急性肺栓塞的诊断价值[J].国际病理科学与临床杂志,2017,37(2):315-318,4.
