高校化学工程学报2017，Vol.31Issue(2)：270-275,6.DOI:10.3969/j.issn.1003-9015.2017.00.022
克拉维酸在乙酸乙酯中的稳定性
Stability of Clavulanic Acid in Ethyl Acetate
胡春燕 1秦超 1王旭东 1董悦生 1修志龙 1李树有 2冯涛 2王启斌2
作者信息
- 1. 大连理工大学生命科学与技术学院,辽宁大连 116024
- 2. 国药集团威奇达药业有限公司,山西大同 037000
- 折叠
摘要
Abstract
Ethyl acetate decoloring liquids from downstream processing of clavulanic acid was used to study clavulanic acid stability in ethyl acetate solution. Degradation of clavulanic acid in ethyl acetate solution under different water contents was studied at different temperatures (0, 5, 20 and 30 ℃) and pH (2±0.5). Parameters of degradation kinetics and thermodynamics such as reaction rate constant, half-life, reaction activation energy,enthalpy change and free energy were obtained through fitting data from degradation experiments and kinetic/thermodynamic analysis. It is concluded that clavulanic acid is more stable in organic solvents than in aqueous solution. Degradation increases with the increase of water content, and the results show that the degradation reaction is an endothermic and no-spontaneous reaction.关键词
克拉维酸/乙酸乙酯/降解动力学/降解热力学/稳定性Key words
clavulanic acid/ethyl acetate/kinetics/thermodynamics/stability分类
化学化工引用本文复制引用
胡春燕,秦超,王旭东,董悦生,修志龙,李树有,冯涛,王启斌..克拉维酸在乙酸乙酯中的稳定性[J].高校化学工程学报,2017,31(2):270-275,6.
