华东理工大学学报（自然科学版）2017，Vol.43Issue(2)：220-226,7.DOI:10.14135/j.cnki.1006-3080.2017.02.011
基于HSMM和K-means的纳米孔多级事件检测
Detecting of Multi-level Events in Nanopore Experiments Based on HSMM and K-means
摘要
Abstract
This paper proposes a HSMM and K-means based hybrid algorithm for identifying the multilevel events in nanopore data.By means of K-means to analyze the detected blockade events,the number ofcurrent amplitude level of nanopore data can be identified,which will be taken as the input of the HSMM 's number of hidden states.And then,HSMM is used to identify different level inside multi-level event and deceide the dwell times and amplitude of different levels.In the situation of third-level and fourth-level event,the simulation results show that HSMM is more accurate than Opennanopore software,and can classify the events accurately.关键词
纳米孔/HSMM/K-means/多级事件Key words
nanopore/HSMM/K-means/multi-level events分类
机械制造引用本文复制引用
赖永杭,颜秉勇,王慧锋..基于HSMM和K-means的纳米孔多级事件检测[J].华东理工大学学报（自然科学版）,2017,43(2):220-226,7.基金项目
国家重大仪器专项(21327807) （21327807）
