中医学报2017，Vol.32Issue(4)：590-593,4.DOI:10.16368/j.issn.1674-8999.2017.04.154
退白汤的急性毒性实验研究
Acute Toxicity Test for Anti-Vitiligo Tang
摘要
Abstract
Objective:To observe the acute toxicity of mice by intragastric infusion for Anti-vitiligo Tang,and the evaluation of its safety.Methods:The acute toxic reaction of mice was measured after oral administration of Anti-vitiligo Tang,with the dose of 1 360 g crude drug/(kg · d)-1 (equivalent to 480 times the adult clinical daily dosage)by intragastric infusion,14 days were observed after administration,and the toxic reaction and death status of mice were recorded in detail.Results:Except some mice decreased appetite and the color of stool was brown,other status were all normal,with no animal death and no abnormal visceral organs after anatomical examination.Before medication,food intakes,body mass,body temperatures of normal group were (3.2 ± 0.3) g · d-1,(23.1 ± 1.4) g,(37.2 ± 0.5) ℃,and in Anti-vitiligo Tang group were (3.3 ± 0.4) g · d-1,(22.9 ± 1.2) g,(37.4 ± 0.4) ℃.Comparing two groups with each other,there were no statistical significance (P ＞ 0.05);After medication,food intakes,body mass and body temperatures of normal group were (5.5 ± 0.8) g · d-1,(33.8 ± 3.7) g,(37.1 ± 0.5)℃,and in Anti-vitiligo Tang group were (5.4 ± 0.6) g · d-1,(34.2 ± 3.9) g,(37.2 ± O.4) ℃.Comparing two groups with each other,there were also no statistical significance (P ＞ 0.05).Conclusion:Anti-vitiligo Tang has low toxicity,and good safety,providing the experimental basis for clinical application.关键词
退白汤/急性毒性/摄食量/体质量/体温/小鼠Key words
Anti-vitiligo Tang/acute toxicity/food intakes/body mass/body temperatures/mice分类
医药卫生引用本文复制引用
李亚梅,严霞,盛国荣..退白汤的急性毒性实验研究[J].中医学报,2017,32(4):590-593,4.基金项目
江苏省药学会百特生物药学基金(2015035) （2015035）
江苏省南通市社会发展科技计划项目(HS149131) （HS149131）
江苏省南通市卫计委青年医学人才科研基金(WQ2015074) （WQ2015074）
