河南中医2017，Vol.37Issue(4)：590-593,4.DOI:10.16367/j.issn.1003-5028.2017.04.0209
温肾降浊散对大鼠阳离子化牛血清白蛋白肾小球肾炎模型的影响
The Influence of Spleen-Warming and Turbidity-Removing Powder on C-BSA Glomerulonephritis Model of Rats
摘要
Abstract
Objective:To observe the clinical curative effect of The Influence of Spleen-Warming and Turbidity-Removing Powder on cationic bovine serum albumin (C-BSA) glomerulonephritis model of rats.Methods:Ten rats were randomly chosen into the normal control group,and the left ones were prepared to establish (C-BSA) glomerulonephritis models.The successful model rats were randomly divided into the model group with 9 cases,the ripterygium wilfordii treatment group with 8 cases,Turbidity-Removing Powder high-dosage group with 7cases,and Turbidity-Removing Powder low-dosage group with 9 cases.The ones in TurbidityRemoving Powder high-dosage group were given suspension injection for gavage in the form of 3.3 g · (kg · d)-1,while the ones in Turbidity-Removing Powder low-dosage group were given suspension injection for garage in the form of 0.33 g · (kg · d)-1,once daily.The ones in the ripterygium wilfordii treatment group were given suspension injection for gavage in the form of 10 g · (kg · d)-1,once daily.The ones Normal control group and model control group were given distilled water for sixty-third days.Then the whole blood and urine samples of rats were taken to determinate 24-h urine protein,blood urea nitrogen (BUN),serum creatinine (Scr),three acyl three glycerin (TG),serum total cholesterol (TC) and low density lipoprotein cholesterol (LDL-C) respectively.Results:Compared with the normal control group,the model control group's 24-h urinary protein,Scr,TC,TG,BUN and LDL were all increased;Among of them,the differences in 24-h urine protein,Scr,TC and TG had significant difference (P ＜ 0.05),but BUN and LDL had no significant difference (P ＞ 0.05).Compared with the model group,24-h urinary protein,Scr,TC,TG,BUN,LDL of the ripterygium wilfordii treatment group,Turbidity-Removing Powder high-dosage group,and Turbidity-Removing Powder low-dosage group were all decreased,Among of them,the differences in 24-h urine protein,Scr,TC and TG had significant difference (P ＜ 0.05),but BUN and LDL had no significant difference (P ＞ 0.05).Compared with the ripterygium wilfordii treatment group,each index had no significant difference in Turbidity-Removing Powder high-dosage group,and Turbidity-Removing Powder low-dosage group (P ＞ 0.05),and they were equivalent to tripterygium glycosides in functions.Conclusion:Spleen-Warming and Turbidity-Removing Powder has a remarkable clinical curative effect on C-BSA glomerulonephritis model of rats.关键词
温肾降浊散/阳离子化牛血清白蛋白/肾炎模型/大鼠Key words
Spleen-Warming and Turbidity-Removing Powder/bovine serum albumin/glomerulonephritis model/rats分类
医药卫生引用本文复制引用
牛春影,刘国良,李艳薇,胡中花,刘海洋,刘斌..温肾降浊散对大鼠阳离子化牛血清白蛋白肾小球肾炎模型的影响[J].河南中医,2017,37(4):590-593,4.基金项目
黑龙江省自然科学基金项目(编号:H201328) （编号:H201328）
黑龙江省教育厅科学技术研究项目(编号:12541758) （编号:12541758）
中央级公益性科研院所基本科研业务专项(编号:YZYN-13-02) （编号:YZYN-13-02）
黑龙江中医药大学校级基金(编号:2012-035082) （编号:2012-035082）
