湖南中医药大学学报2017，Vol.37Issue(5)：473-476,4.DOI:10.3969/j.issn.1674-070X.2017.05.003
护卵汤对多周期促排卵小鼠子宫内膜ER/PR蛋白表达的影响
Effects of Huluan Decoction on Expression of ER and PR in Endometrium of Multi-Period Ovulation Induction Mice
摘要
Abstract
Objective To observe the effects of Huluan decoction on expression of ER and PR in endometrium of multi-period ovulation induction mice, and to provide more related basis for the effectiveness of Huluantang assisting in vitro fertilization and embryo transfer (IVF-ET). Methods The multi-period ovulation induction mice models were built. The Chinese medicine group was administrated with Huluan decoction, the normal group was given no drugs. The morphology of endometrium and expression of ER and PR in endometrium were observed on the 2nd day and the 5th day of pregnant (P2 and P5). Results Compared with those in normal group and Chinese medicine group, the growth and development of the P5 endometrium in the model group was unhealthy. Compared with those in the model group, the expression of ER in the P2 and P5 endometriumin of Chinese medicine group increased significantly (P<0.05). Compared with those in the normal group, the expression of ER in the P5 endometrium of the Chinese medicine group increased significantly (P<0.05). The expression of PR in the P2 and P5 endometrium in the Chinese medicine group increased more obviously than those in model group and normal group (P<0.01). Conclusion The Chinese medicine of Huluan decoction could promote the growth and development of endometrium and increase the expression of ER and PR in endometrium, which may improve the endometrial receptivity in multi-period ovulation induction mice.关键词
护卵汤/雌激素受体/孕激素受体/子宫内膜容受性/小鼠Key words
Huluan decoction/ER/PR/endometrial receptivity/mice分类
医药卫生引用本文复制引用
申奏秦旋,申可佳,熊桀,王肖,王宇航,吴华英,邓文..护卵汤对多周期促排卵小鼠子宫内膜ER/PR蛋白表达的影响[J].湖南中医药大学学报,2017,37(5):473-476,4.基金项目
国家自然科学基金项目资助(81303003,81403427) （81303003,81403427）
湖南省大学生研究性学习和创新性实验计划项目资助(181). （181）
