化学工程2017，Vol.45Issue(1)：22-26,5.DOI:10.3969/j.issn.1005-9954.2017.01.005
树脂吸附法从发酵液中提取红霉素的工艺研究
Recovery of erythromycin from fermentation broth using membrane filtration and macroporous resin adsorption
朱晟 1朱家文 2陈葵2
作者信息
- 1. 上海电力学院环境与化学工程学院,上海200090
- 2. 华东理工大学化学工程研究所,上海200237
- 折叠
摘要
Abstract
To solve the problems in the traditional erythromycin (EM) production process,a new process for recovery of EM from fermentation broth,including membrane filtration,macroporous resin adsorption,impurity washing,EM desorption,EM thiocyanate crystallization,and resin regeneration,was proposed.Using EM fermentation broth as starting material,the technological conditions and practical effects of each unit operation were studied and optimized.The ceramic membrane with the pore size of 50 nm was selected for the pretreatment of fermentation broth.The average decolorization ratio,the average deproteinization ratio and the average EM yield were 54.0％,67.5％ and 92.5％,respectively.The macroporous resin adsorption was used for the concentration of EM from filtrate.The purity of final product had an increase of 2.31％ compared with the original process with a yield of 92.6％.The mixture of volume fraction 50％ acetone and 50％ 0.40 mol/L NaOH solution was chosen to regenerate the exhausted resin,and the saturated adsorption capacity of the regenerated resin was no less than 80％ of that of the fresh resin.关键词
红霉素/发酵液/膜过滤/大孔树脂/吸附Key words
erythromycin/fermentation broth/membrane filtration/macroporous resin/adsorption分类
化学化工引用本文复制引用
朱晟,朱家文,陈葵..树脂吸附法从发酵液中提取红霉素的工艺研究[J].化学工程,2017,45(1):22-26,5.
