海洋科学2017，Vol.41Issue(1)：24-29,6.DOI:10.11759/hykx20160408001
壳聚糖碱性氨基酸衍生物的合成及抑菌活性研究
Synthesis and antibacterial activities of basic amino acid-modified chitosan derivatives
摘要
Abstract
In this study, three basic amino acids were used to modify chitosan to improve its antibacterial activity. Lysine-modified chitosan, arginine-modified chitosan, and histidine-modified chitosan were synthesized, and their structures were characterized using Fourier-transform infrared, magnetic resonance spectra (1H-NMR), and ele-mental analysis. The results showed that the amino acids were successfully grafted onto chitosan. The antibacterial activities of these derivatives against Escherichia coli and Staphylococcus aureus were investigated. The MIC of lysine-modified chitosan, arginine-modified chitosan, and histidine-modified chitosan on S.aureus was 320, 160, 320, and 640 μg/mL, respectively, and the MIC on E.coli was 320, 320, 320, and 640 μg/mL, respectively. All three basic amino acid-modified chitosan derivatives exhibited better antibacterial activity than chitosan.关键词
壳聚糖/碱性氨基酸/衍生物/抑菌活性Key words
Chitosan/basic amino acids/derivatives/antibacterial activity分类
生物科学引用本文复制引用
黄勇,刘松,秦玉坤,邢荣娥,李克成,于华华,岳洋,李俨,李鹏程..壳聚糖碱性氨基酸衍生物的合成及抑菌活性研究[J].海洋科学,2017,41(1):24-29,6.基金项目
中国科学院 STS 计划项目(KFJ-SW-STS-143) （KFJ-SW-STS-143）
国家海洋公益性项目(201305016-2、201405038-2) （201305016-2、201405038-2）
NSFC-山东联合资助项目(U1406402-5)CAS STS Program, No.KFJ-SW-STS-143 （U1406402-5）
The Public Sci-ence and Technology Research Funds Projects of Ocean, No.201305016-2, No.201405038-2 （）
NSFC-Shandong Union project, No. U1406402-5 （）
