解剖学杂志2017，Vol.40Issue(2)：141-144,152,封2,6.DOI:10.3969/j.issn.1001-1633.2017.02.005
适量饮用贵州某食用白酒对Ⅰ型糖尿病小鼠胰岛β细胞的影响
Effects of moderate consumption of Guizhou liquor on beta cells of mice with type Ⅰ diabetes mellitus
摘要
Abstract
Objective:To investigate the effects of moderate consumption of Guizhou liquor on β cells of mice with type Ⅰ diabetes mellitus (TIDM) and to explore the possible mechanism.Methods:Male C57BL/6J mice were divided into 3 groups:liquor consumption group,diabetes group and diabetes-liquor consumption group.Fasting blood glucose was measured and the pancreas was assessed by immunohistochemical SABC,real-time PCR,image analysis and morphmetric methods in the study.Results:Within the diabetes group and diabetes-liquor consumption group,fasting blood glucose increased above 11.1 mmol/L.The fasting blood glucose,values of mean density,numerical density on area (NA) of β cells and expression of insulin mRNA had no obvious change in liquor consumption group.Mean density of β cells in diabetes group and diabetesliquor consumption group increased,while NA and expression of insulin mRNA in these groups decreased.Conclusion:β cells are not influenced by liquor consumption within the set dosage and duration in the study.Moderate liquor consumption doesn't aggravate the damage of β cells in TIDM mice.关键词
Ⅰ型糖尿病/β细胞/白酒/胰岛素/小鼠Key words
type Ⅰ diabetes mellitus/β cell/liquor/insulin/mouse引用本文复制引用
李容瑢,李一欣,夏白娟,尹丹,刘昊,梁文妹..适量饮用贵州某食用白酒对Ⅰ型糖尿病小鼠胰岛β细胞的影响[J].解剖学杂志,2017,40(2):141-144,152,封2,6.基金项目
贵州省教育厅“125”重大科技专项[黔教合重大专项字(2012)007] （2012）
贵州省国际合作计划项目(黔科合外G字[2010]7017号) （黔科合外G字[2010]7017号）
