解剖学杂志2017，Vol.40Issue(2)：163-167,5.DOI:10.3969/j.issn.1001-1633.2017.02.011
慢性间歇性低压低氧对老年大鼠自发运动行为及黑质多巴胺能神经元的影响
Effects of chronic intermittent hypobaric hypoxia on motor behavior and substantia nigra dopaminergic neurons in aged rats
摘要
Abstract
Objective:To study the effects of chronic intermittent hypobaric hypoxia (CIHH) on motor behavior and substantia nigra dopaminergic neurons in aged rats.Methods:The motor behavior of the aged rats treated by CIHH for 30 days was examined by the open field test.Expression of tyrosine hydroxylase (TH) and dopamine transporter (DAT) of substantia nigra dopaminergic neurons in aged rats were examined by Western blotting and quantitative PCR.Results:Compared to adult rats,sniffing behavior,exploratory behavior,motor behavior and grooming behavior declined significantly in aged rats.CIHH significantly ameliorated the parameters of sniffing behavior,exploratory behavior and motor behavior,but not restore it to the level of adult rats.The parameters of grooming behavior were not affect by CIHH.The expression of TH and DAT in substantia nigra dopaminergic neurons was down-regulated in aged rats.CIHH significantly enhanced TH and DAT expression,but not restore them to the level of adult rats.Conclusion:CIHH ameliorates the declined locomotor activity and improve the expression of TH and DAT in dopaminergic neurons in aged rats.关键词
慢性间歇性低压低氧/运动行为/多巴胺/老年大鼠Key words
chronic intermittent hypobaric hypoxia/motor behavior/dopamine/aged rats引用本文复制引用
李媛,张放,张国梁,王力,靳玉川,樊平,石葛明..慢性间歇性低压低氧对老年大鼠自发运动行为及黑质多巴胺能神经元的影响[J].解剖学杂志,2017,40(2):163-167,5.基金项目
河北省卫生厅青年科技基金(20090310) （20090310）
