解剖学杂志2017，Vol.40Issue(2)：176-180,5.DOI:10.3969/j.issn.1001-1633.2017.02.014
负极性驻极体与5-氟尿嘧啶对大鼠创面愈合的影响
Effect of negative polypropylene electret and 5-fluoorouracii on skin wound healing of rats
摘要
Abstract
Objective:To compare the effect of negative polypropylene(PP) electrets with different surface potentials with that of the 5 fluoorouracil(5-FU) on skin wound healing of rats.Methods:The corona charged electret patches with different surface potentials,5-FU patch and 2 000 V PP electret 5-FU patch were prepared.By means of surface potential measurement,optical microscope,the stability of the electrostatic field of electret patch and electrets drug patch,as well as the effect of the above three kinds of patches to wound healing were studied.Results:All the electret and electret drug patches had stable electrostatic field to act on the wound surface.The wound healing effect of electret patch was proportional to the surface potential of the electret.5-FU inhibited the wound healing.However,the electret drug patch could reduce the inhibitory action of the 5-FU to would healing.Conclusion:Negative PP electret can promote the wound healing,while 5-FU delays the wound healing.The combination of electret and 5-FU could be a better way to regulate the wound healing and inhibit the growth of hyperplastic scar.关键词
驻极体/5-氟尿嘧啶/创面愈合/静电场/大鼠Key words
electret/5-fluoorouracil/wound healing/electrostatic field/rat引用本文复制引用
黄平,徐立丽,梁媛媛,郭鑫,梁合鹃,崔黎丽,江键..负极性驻极体与5-氟尿嘧啶对大鼠创面愈合的影响[J].解剖学杂志,2017,40(2):176-180,5.基金项目
国家自然科学基金(51477175) （51477175）
