军事医学2017，Vol.41Issue(4)：291-294,4.DOI:10.7644/j.issn.1674-9960.2017.04.010
法可林的合成研究
Synthesis of phacolysin
别旋 1张珩 1杨艺虹 1曹爽 1吴炜1
作者信息
- 1. 武汉工程大学绿色化工过程教育部重点实验室,武汉 430073
- 折叠
摘要
Abstract
Objectve To optimize the synthesis process of phacolysin 1 for industrial production.Methods Phacolysin as the target product was synthesized with a total yield of 40.7% by condensation reaction of O-phenylenediamine and sulfonation reaction.The yield reported in literature was 24.8%.Results Such factors as the ratio of the raw materials,the catalyst,and the reaction time were inveatigated and optimized to make the reaction conditions mild and easy to control with less side effect.Conclusion The structure is confirmed by 1HNMR and MS,and the optimized process is more suitable for industrial production.关键词
法可林/眼药水/白内障/工艺学,制药/色谱法,高压液相/合成Key words
phacolysin/ophthalmis solutions/cataract/technology/pharmaceutical/chromatography/high pressure liquid/synthesis分类
医药卫生引用本文复制引用
别旋,张珩,杨艺虹,曹爽,吴炜..法可林的合成研究[J].军事医学,2017,41(4):291-294,4.
