检验医学与临床2017，Vol.14Issue(9)：1206-1208,1212,4.DOI:10.3969/j.issn.1672-9455.2017.09.002
自体外周血造血干细胞移植治疗高危难治恶性淋巴瘤96例疗效分析
Curative effect analysis of autologous peripheral blood hematopoietic stem cell transplantation in 96 patients with lymphoma
摘要
Abstract
Objective To discuss the efficacy of autologous hematopoietic stem cell transplantation(AHSCT) in patients with malignant lymphoma.Methods A total of 96 patients with malignant lymphoma were enrolled in this study;and all of them were treated with courses of chemotherapy before AHSCT.All the basic clinical characteristics;status before AHSCT and the prognosis situations were collected together.SPSS19.0 was used in the Kaplan-Meier survival analysis and the prognostic factors were analyzed by Cox model for retrospectively analyzing the overall efficacy and related prognostic factors.Results Totally 94 of the 96 patients achieved hematopoietic reconstitution;and the average reconstitution time of granulocyte and platelets were 9 days (7-19 days) and 16 days (10-37 days).With a median follow-up time of 26 months (0-74 months);the 3-year overall survival (OS) rate was 86.4% and the 3-year progression-free survival (PFS) rate was 70.3%.The higher IPI score (higher than 2 points);not getting complete remission (CR) before AHSCT;high lactate dehydrogenase (LDH) level and bone marrow infiltration suggested poor prognosis;in which the disease status before transplantation and LDH level were revealed as two prognostic factors independently.Conclusion High-dose chemotherapy combined with AHSCT is a safe and effective therapy for patients with malignant lymphoma.Disease status before transplantation and LDH level are two independently prognostic factors in this study.关键词
外周血造血干细胞移植/淋巴瘤/预后/个体化治疗Key words
autologous hematopoietic stem cell transplantation/lymphoma/prognostic factors/individualized treatment分类
社会科学引用本文复制引用
张丽霞,王利,刘林,陈建斌,肖青,唐晓琼,张红宾,王建渝,陈礼平,王欣..自体外周血造血干细胞移植治疗高危难治恶性淋巴瘤96例疗效分析[J].检验医学与临床,2017,14(9):1206-1208,1212,4.基金项目
国家自然科学基金资助项目(81250034) （81250034）
重庆市卫生与计划生育委员会资助项目(2013-2-023). （2013-2-023）
