检验医学与临床2017，Vol.14Issue(9)：1218-1219,1223,3.DOI:10.3969/j.issn.1672-9455.2017.09.006
深部酵母菌感染分布及耐药性分析
Distribution and drug resistance of deeper infection caused by yeasts
摘要
Abstract
Objective To investigate distribution and drug resistance of deeper infection caused by yeasts,and to provide reference of using antifungal drugs in clinical and control of nosocomial infection.Methods A total of 764 strains of yeasts were isolated from Tongji Hospital during 2010-2015 and infected distributions of the pathogens were investigated.ATB FUNGUS 3 kit was used to detect drug resistance of the 764 strains of yeasts which was commonly used.Results The number of strains of yeasts which isolated from blood,abdominal dropsy and bronchoscopy lavage were 184 (24.1%),151 (19.8%) and 146 (19.1%) respectively.The sensitivity of 764 yeast strains to fluconazole,amphotericin B,itraconazole,5-fluorocytosine and voriconazole were 91.3%,73.4%,96.6%,97.7% and 95.4%,respectively.The resistance rates of Candida albicans,Candida tropicalis,Candida parapsilosis and Cryptococcus neoformans to five kinds of antifungal agents were all below 10%.Conclusion Deeper infection caused by Candida albicans is the most common.The sensitivity of yeasts in vitro susceptibility test to fluconazole,voriconazole,5-fluorocytosine and amphotericin B are higher,but lower to itraconazole.Candida albicans,Candida tropicalis,Candida parapsilosis and Cryptococcus neoformans are sensitive to triazole antifungal drugs.关键词
酵母菌/抗真菌药物/耐药性Key words
yeast/antifungus drugs/drug resistance分类
社会科学引用本文复制引用
熊志刚,曹文,陈中举,孙自镛..深部酵母菌感染分布及耐药性分析[J].检验医学与临床,2017,14(9):1218-1219,1223,3.基金项目
国家"十二五"科技重大专项子课题(2012ZXl0004207-004). （2012ZXl0004207-004）
