检验医学与临床2017，Vol.14Issue(9)：1262-1265,4.DOI:10.3969/j.issn.1672-9455.2017.09.022
异基因造血干细胞移植治疗急性淋巴细胞白血病25例的临床分析
The clinical analysis of allogeneic hematopoietic stem cell transplantation treatment in 25 patients with acute lymphoblastic leukemia
苗巧 1汪晶 1蒋曲 1邓雪梅 1刘香君 1张红宾1
作者信息
- 1. 重庆医科大学附属第一医院血液内科 400016
- 折叠
摘要
Abstract
Objective To study the effect of allogeneic hematopoietic stem cell transplantation (allo-HSCT) in treatment of patients with acute lymphoblastic leukemia (ALL).Methods A total of 25 patients,including 7 cases with positive Philadelphia chromosome (Ph+) ALL and 18 cases with Ph- ALL,were treated with allo-HSCT in our hospital from March 2009 to August 2015.All cases included 21 cases in complete remission(CR)1,2 cases in CR2,1 cases in partial remission(PR) and 1 cases in un-remission(UR) before allo-HSCT treatment.Seven cases were HLA-identical sibling,three cases were HLA-matched unrelated volunteer and 15 cases were haploidentical sibling.Two patients underwent bone marrow transplantation (BMT) and peripheral blood stem cell transplantation (PBSCT).Conditioning regimen:16 cases received busulfan/cytoxan (Bu/Cy),8 cases received total body irradiation (TBI)/Cy and 1 case received Flu/Bu.Cyclosporine A (CsA),mycophenolate mofetil (MMF),antithymocyte globulin (ATG) and methotrexate (MTX) were used to prevent acute graft versus host disease (aGVHD).Results All patients achieved hematopoietic reconstitution after allo-HSCT.With a follow-up of 12 months,there were 14 cases with disease-free survival (DFS) for 8.5 to 45.0 months after allo-HSCT treatment.Overall survival rate was 60%.The mortality was 40% (10/25) owing to aGVHD,disseminated infection,TA-TMA,relapse and other complications.Conclusion Allo-HSCT is an effective way for the treatment of ALL,and methods that could reduce the relapse and severe complications after allo-HSCT needs further research.关键词
异基因造血干细胞移植/急性淋巴细胞白血病/复发/移植物抗宿主病/突变Key words
allogeneic hematopoietic stem cell transplantation/acute lymphoblastic leukemia/relapse/graft versus host disease/mutation分类
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苗巧,汪晶,蒋曲,邓雪梅,刘香君,张红宾..异基因造血干细胞移植治疗急性淋巴细胞白血病25例的临床分析[J].检验医学与临床,2017,14(9):1262-1265,4.
