临床肝胆病杂志2017，Vol.33Issue(3)：438-444,7.DOI:10.3969/j.issn.1001-5256.2017.03.008
肝窦内皮细胞在肝纤维化发生发展中的机制及相关治疗策略
Role of liver sinusoidal endothelial cells in the development and progression of liver fibrosis and related therapeutic strategy
杜艳芹 1吴珺 1杨东亮1
作者信息
- 1. 华中科技大学同济医学院附属协和医院感染科,武汉430022
- 折叠
摘要
Abstract
Liver sinusoid endothelial cells are the first defense mechanism that protects the liver against various injuries,and they also play a significant role in the development of liver fibrosis and liver cirrhosis caused by chronic liver injury.They are involved in liver fibrosis by mediating liver inflammation,participating in sinusoid capillarization and revascularization,activating hepatic stellate cells,secreting many proinflammatory cytokines,participating in extracellular matrix formation,and mediating liver microcirculation disturbance.Clarification of these mechanisms helps to identify new targets and develop new regimens for the treatment of liver fibrosis.关键词
肝硬化/肝窦内皮细胞/治疗Key words
liver cirrhosis/liver sinusoidal endothelial cells/therapy分类
医药卫生引用本文复制引用
杜艳芹,吴珺,杨东亮..肝窦内皮细胞在肝纤维化发生发展中的机制及相关治疗策略[J].临床肝胆病杂志,2017,33(3):438-444,7.
