临床肝胆病杂志2017，Vol.33Issue(3)：558-562,5.DOI:10.3969/j.issn.1001-5256.2017.03.036
自然杀伤细胞对肝星状细胞的调控及其在肝纤维化中的作用
Regulatory effect of natural killer cells on hepatic stellate cells and their role in liver fibrosis
摘要
Abstract
Hepatic stellate cell (HSC) activation is closely associated with the progression of liver fibrosis.As an important component of the innate immune system,natural killer (NK) cells are enriched in the liver and play a key role in host defense against viral infection and tumor,and their anti-fibrotic effect has also been confirmed.NK cells can reduce liver fibrosis by killing early-activated or senescent HSCs or secreting interferon-γ.This article summarizes related research advances in recent years,and introduces the molecular immunological mechanism of NK cells in regulating HSCs and their potential anti-fibrotic effect based on the function and phenotype of NK cells and HSCs.关键词
肝硬化/杀伤细胞,天然/肝星状细胞/综述Key words
liver cirrhosis/killer cells, natural/hepatic stellate cells/review分类
医药卫生引用本文复制引用
李天阳,涂正坤,苏立山..自然杀伤细胞对肝星状细胞的调控及其在肝纤维化中的作用[J].临床肝胆病杂志,2017,33(3):558-562,5.基金项目
国家自然科学基金(81373143,81571535) （81373143,81571535）
