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基质金属蛋白酶与肝纤维化关系的研究进展

戈宏焱 张仕华

临床肝胆病杂志2017,Vol.33Issue(3):563-566,4.
临床肝胆病杂志2017,Vol.33Issue(3):563-566,4.DOI:10.3969/j.issn.1001-5256.2017.03.037

基质金属蛋白酶与肝纤维化关系的研究进展

Research advances in association between matrix metalloproteinases and liver fibrosis

戈宏焱 1张仕华2

作者信息

  • 1. 内蒙古民族大学附属医院,内蒙古民族大学临床医学院消化内科,内蒙古通辽028000
  • 2. 内蒙古民族大学,内蒙古通辽028000
  • 折叠

摘要

Abstract

Liver injury caused by various reasons can lead to the occurrence of liver fibrosis,which is the pathological process from chronic liver disease to liver cirrhosis.Liver fibrosis is caused by the increased synthesis and reduced degradation of extracellular matrix (ECM).ECM is mainly degraded by matrix metalloproteinases (MMP),and therefore,MMP play an important role in the progression and.diagnosis/treatment of liver fibrosis.This article reviews the research advances in the association between MMP and liver fibrosis.

关键词

肝硬化/基质金属蛋白酶类/综述

Key words

liver cirrhosis/matrix metalloproteinases/review

分类

医药卫生

引用本文复制引用

戈宏焱,张仕华..基质金属蛋白酶与肝纤维化关系的研究进展[J].临床肝胆病杂志,2017,33(3):563-566,4.

基金项目

内蒙古自然科学基金面上项目(2015MS0805) (2015MS0805)

临床肝胆病杂志

OA北大核心CSTPCD

1001-5256

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