摘要
Abstract
Objective To compare the hemostatic effect of intravenous and topical tranexamic acid(TXA) in primary unilateral total knee arthroplasty(TKA).Methods According to the application with or without TXA,the 380 cases underwent primary unilateral TKA were divided into three groups : ① the intravenous drip group: intraoperative intravenous infusion of TXA 30 mg/kg, with a total of 120 cases;② local injection group:1.5 g TXA was dissolved in 50 ml normal saline, intraoperative intra-articular injection point, 136 cases;③ no application group: no TXA used during surgery, with 124 cases.The limb circumference were measured preoperatively and postoperatively at 1,2 and 3 d, the blood loss, postoperative drainage volume, blood transfusion and deep venous thrombosis (DVT) were observed.Results All patients were followed up for 12~18 months.Three groups of operation time, blood loss, postoperative drainage, allogeneic blood transfusion, DVT and operative limb circumference showed no significant difference (P>0.05).the rate of blood transfusion, hidden blood loss, the total volume of postoperative blood loss: intravenous drip group, local injection group were significantly lower than that of no application group, the differences were statistically significant (P<0.05).Intravenous drip group and local injection group had no significant difference (P>0.05).Conclusions In the first unilateral TKA, intravenous and local application of TXA have good hemostatic effect,which can significantly reduce the bleeding volume in patients, and do not increase the risk of DVT.There are no significant differences between the two routes of administration.关键词
氨甲环酸/全膝关节置换术/止血Key words
tranexamic acid/total knee arthroplasty/hemostasis分类
医药卫生
