临床与实验病理学杂志2017，Vol.33Issue(3)：237-240,4.DOI:10.13315/j.cnki.cjcep.2017.03.001
乳腺癌中RNF2的表达及其临床意义
Expression of RNF2 in breast carcinoma and its significance
摘要
Abstract
Purpose To investigate the expression of RNF2 in breast disease tissues and cell lines,and to analyze the association between expression of RNF2 and clinicopathological characteristics in breast carcinoma.Methods Expression of RNF2 protein and mRNA levels was detected using immunohistochemistry of EnVision two-step and qRT-PCR in breast carcinoma and benign breast disease as well as in cell lines.Results RNF2 expression was sigmificantly higher in breast carcinoma tissue specimens compared with benign breast disease specimens (P ＜0.05).Besides,the expression of RNF2 protein was significantly associated to tumor size,lymph node status and TNM stage (P ＜ 0.05 for both),but was not related to age,histological grade,the expression of ER,PR and HER-2 (P ＞ 0.05 for both).Higher expression of RNF2 mRNA was detected in breast carcinoma cell lines compared with breast epithelial cell lines (P ＜ 0.05).Conclusion RNF2 is overexpressed in breast carcinoma and can be a potential therapeutic target for breast carcinoma.关键词
乳腺肿瘤/环指蛋白2/免疫组织化学/qRT-PCRKey words
breast neoplasm/RNF2/immunohistochemistry/qRT-PCR分类
医药卫生引用本文复制引用
李庆,吴正升,沈玉君,冯利杰,沈玉先..乳腺癌中RNF2的表达及其临床意义[J].临床与实验病理学杂志,2017,33(3):237-240,4.基金项目
国家自然科学基金(81472493、81372576)、安徽省学术和技术带头人及后备人选科研活动经费(2016H074) （81472493、81372576）
