临床与实验病理学杂志2017，Vol.33Issue(3)：282-286,5.DOI:10.13315/j.cnki.cjcep.2017.03.011
细胞免疫化学p16/Ki-67双染预测子宫颈上皮内高级别瘤变
Study of predictive value for detection of high-grade cervical intraepithelial neoplasia by p16/Ki-67 dual-stained liquid-based cytology
摘要
Abstract
Purpose To study of predictive value for detection of high-grade cervical intraepithelial neoplasia (CIN2 +) by p16/Ki-67 dual-stained liquid-based cytology.Methods Random collection of 123 women including 103 samples of atypical squamous cell of undetermined significance (ASC-US) and above with results of high-risk human papillomavirus (HR-HPV)testing and cervical biopsy,20 samples of negative for intraepithelial lesion or malignancy (NILM) by using immunocytochemical p16/Ki-67 dual-stained and the morphology assessment.Results In normal control group,the expression of p16/Ki-67 dual-stained in squamous epithelial cells were negative.Sensitivity of p16/Ki-67 dual-staind cytology for biopsy-confirmed CIN2 + was 66.67％ (ASC-US),91.67％ (LSIL) and 92.86％ (HSIL),specificity rates were 95.92％ (ASC-US),95.00％ (LSIL) and 0 (HSIL),positive predictive value were 50.00％ (ASC-US),91.67％ (LSIL) and 92.86％ (HSIL),negative predictive value were 97.92％ (ASC-US),95.00％(LSIL) and 0 (HSIL),respectively.Condusion p16/Ki-67 dual-stained cytology are improved obviously the predictive value for detection of CIN2 +,p16/Ki-67 dual-stained cytology may efficiently complement HPV-based screening programs to prevent cervical cancer.关键词
子宫颈上皮内瘤变/p16/Ki-67双染/细胞免疫化学/高危型人乳头瘤病毒Key words
cervical intraepithelial neoplasia/p16/Ki-67 dual staining/immunocytochemistry/HR-HPV分类
医药卫生引用本文复制引用
印永祥,赵华,梁洁,张金秋,赵敏,王家俊..细胞免疫化学p16/Ki-67双染预测子宫颈上皮内高级别瘤变[J].临床与实验病理学杂志,2017,33(3):282-286,5.基金项目
无锡市卫计委妇幼健康成果技术推广(FYTG2016-2)、无锡市卫生计生科技成果和适宜技术推广(T201645) （FYTG2016-2）
